The Rhizome Mixture of Anemarrhena asphodeloides and Coptis chinensis Attenuates Mesalazine-Resistant Colitis in Mice

Table 2

Properties of mice with TNBS-induced colitis caused by treatment with a single or repetitive TNBS in the absence or presence of mesalazine.

Parameter	TC; (TNBS)	MTC; (modified TNBS)	MRC; (modified TNBS plus mesalazine)
Myeloperoxidase	++	+	+
TNF-α	++	+	+
IL-1β	++	+	+
IFNγ	++	++	++
IL-5	−	0	0
IL-10	−	−	−
IL-17	+	++	++
T-bet	+	++	+
GATA3	−	0	0
RORγt	++	++	+
Foxp3	−	−	−
Mesalazine resistance	0	0	++

Mice with TNBS-induced colitis (TC) were intrarectally treated with TNBS (0.2 mL of 5% (w/v) TNBS solution) at once.
Mice with modified TNBS-induced colitis (MTC) were intrarectally treated with TNBS (0.1 mL of 2.5% (w/v) TNBS solution) four times.
Mice with MRC were intrarectally treated with TNBS (0.1 mL of 2.5% (w/v) TNBS solution) four times and mesalazine three times.
Expression levels of parameters are indicated as follows: 0, no induction or no suppression; +, moderate induction; ++, strong induction; −, moderate suppression.