Personalized Kampo Medicine Facilitated Both Cytotoxic T Lymphocyte Response and Clinical Benefits Induced by Personalized Peptide Vaccination for Advanced Esophageal Cancer

Table 2

Toxicities.

	PPV with PKM ()						PPV without PKM ()						value
	G1	G2	G3	G4	G5	Total	G1	G2	G3	G4	G5	Total
Injection site reaction	12	2				14	6	1				7	0.88
Blood/bone marrow
Anemia		4				4	1	2	1			4	0.22
Leukocytopenia	1	2				3	2					2	0.69
Neutropenia	1					1						0	0.48
Lymphopenia	1	6				7	1	1	1			3	0.85
Thrombocytopenia	1					1	1					1	0.58
Laboratory
AST elevation						0	2	1	2			5	<0.01
ALT elevation						0	1		3			4	<0.01
GGT elevation						0	2	2				4	<0.01
ALP elevation						0	4		2			6	<0.01
CRP elevation	1					1	1					1	0.58
D-dimer elevation	1					1						0	0.48
PT (%) decrease		1				1						0	0.48
Creatinine elevation						0		1				1	0.14
Hyperbilirubinemia						0	1			1		2	0.04
Hypoalbuminemia	4	3				7	1	4				5	0.39
Hyponatremia	2					2	1		1			2	0.42
Hyperkalemia	1					1	2					2	0.18
Hyperuricemia						0	1			1		2	0.04
Hyperglycemia	1					1	1					1	0.58
Hyperlipidemia	1					1	1	1				2	0.18
Gastrointestinal
Anorexia	2		4			6			1			1	0.25
Dysphagia			1		1	2						0	0.31
Diarrhea		1				1						0	0.48
Esophageal stenosis			1			1						0	0.48
Respiratory
Hoarseness	1					1						0	0.48
Pleural effusion		1				1						0	0.48
Dyspnea	1					1					1	1	0.58
Pneumonitis			1			1					2	2	0.18
Cough	2	1				3						0	0.21
Urinary
Hematuria	1					1						0	0.48
Tumor pain		1				1	1					1	0.58
Urticaria	1					1						0	0.48
Fracture	1					1						0	0.48
Malaise		2				2						0	0.31
Fever	2					2						0	0.31
Edema limbs	1					1		1				1	0.58

AST: aspartate aminotransferase, ALT: alanine aminotransferase, and GGT: gamma-glutamyl transferase
ALP: alkaline phosphatase.