Evidence-Based Complementary and Alternative Medicine / 2016 / Article / Tab 2 / Research Article
Personalized Kampo Medicine Facilitated Both Cytotoxic T Lymphocyte Response and Clinical Benefits Induced by Personalized Peptide Vaccination for Advanced Esophageal Cancer PPV with PKM ( ) PPV without PKM ( ) valueG1 G2 G3 G4 G5 Total G1 G2 G3 G4 G5 Total Injection site reaction 12 2 14 6 1 7 0.88 Blood/bone marrow Anemia 4 4 1 2 1 4 0.22 Leukocytopenia 1 2 3 2 2 0.69 Neutropenia 1 1 0 0.48 Lymphopenia 1 6 7 1 1 1 3 0.85 Thrombocytopenia 1 1 1 1 0.58 Laboratory AST elevation 0 2 1 2 5 <0.01 ALT elevation 0 1 3 4 <0.01 GGT elevation 0 2 2 4 <0.01 ALP elevation 0 4 2 6 <0.01 CRP elevation 1 1 1 1 0.58 D-dimer elevation 1 1 0 0.48 PT (%) decrease 1 1 0 0.48 Creatinine elevation 0 1 1 0.14 Hyperbilirubinemia 0 1 1 2 0.04 Hypoalbuminemia 4 3 7 1 4 5 0.39 Hyponatremia 2 2 1 1 2 0.42 Hyperkalemia 1 1 2 2 0.18 Hyperuricemia 0 1 1 2 0.04 Hyperglycemia 1 1 1 1 0.58 Hyperlipidemia 1 1 1 1 2 0.18 Gastrointestinal Anorexia 2 4 6 1 1 0.25 Dysphagia 1 1 2 0 0.31 Diarrhea 1 1 0 0.48 Esophageal stenosis 1 1 0 0.48 Respiratory Hoarseness 1 1 0 0.48 Pleural effusion 1 1 0 0.48 Dyspnea 1 1 1 1 0.58 Pneumonitis 1 1 2 2 0.18 Cough 2 1 3 0 0.21 Urinary Hematuria 1 1 0 0.48 Tumor pain 1 1 1 1 0.58 Urticaria 1 1 0 0.48 Fracture 1 1 0 0.48 Malaise 2 2 0 0.31 Fever 2 2 0 0.31 Edema limbs 1 1 1 1 0.58
AST: aspartate aminotransferase, ALT: alanine aminotransferase, and GGT: gamma-glutamyl transferase ALP: alkaline phosphatase.