Activation of p53/miR-34a Tumor Suppressor Axis by Chinese Herbal Formula JP-1 in A549 Lung Adenocarcinoma Cells

<div>Effects of JP-1 on the AMPK/mTOR and CDK6/pRb cascades in A549 cells. (a) JP-1 decreased the protein levels of CDK6 and phosphorylated pRb (p-pRb) in a dose-dependent manner after 48 h of treatment. (b) JP-1 dose-dependently increased the phosphorylated AMPK<i>α</i> protein (p-AMPK<i>α</i>) and decreased the phosphorylated mTOR (p-mTOR) after 48 h of treatment. Cell lysates were analyzed by Western blot, using GAPDH as the loading control.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 3: Activation of p53/miR-34a Tumor Suppressor Axis by Chinese Herbal Formula JP-1 in A549 Lung Adenocarcinoma Cells 