Myricitrin Protects against Doxorubicin-Induced Cardiotoxicity by Counteracting Oxidative Stress and Inhibiting Mitochondrial Apoptosis via ERK/P53 Pathway

Figure 5

Effects of Dox and myricitrin on the antioxidant capacity in vivo and in vitro. The H9c2 cardiomyocytes were treated with Dox for 36 h in presence or absence of myricitrin (12.5 and 25 μg/mL). The ROS production was visualized using fluorescence microscopy and quantified using an automatic microplate reader ((a) and (b)). The effects of myricitrin on the activities of CAT, GSH-Px, and SOD and the levels of MDA in the H9c2 cells (c) and rat heart tissues (d) were measured using the corresponding detection kits. All data are expressed as the means ± SD ( = 3–8). versus Cont; versus Dox.

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