Herb-Drug Interaction: Effects of Relinqing® Granule on the Pharmacokinetics of Ciprofloxacin, Sulfamethoxazole, and Trimethoprim in Rats

Table 2

Main pharmacokinetic parameters of sulfamethoxazole and trimethoprim alone (control) and after repeated administration of RLQ.

Parameters	Sulfamethoxazole		Trimethoprim
	Control group 2	RLQ group 2	Control group 2	RLQ group 2
(mg/Lh)	1205.36 ± 330.02	443.46 ± 55.36	27.31 ± 12.61	37.28 ± 14.01
(h)	4.26 ± 0.87	4.92 ± 0.76	19.01 ± 10.68	14.11 ± 5.62
(h)	2.0 ± 0.75	2.58 ± 1.31	1.21 ± 0.62	1.3 ± 1.00
(L/h/kg)	0.2 ± 0.07	0.5 ± 0.06	9.18 ± 3.34	6.77 ± 3.15
(L/kg)	1.21 ± 0.53	3.56 ± 0.66	279.34 ± 256.73	124.42 ± 38.34
(mg/L)	129.14 ± 18.39	46.22 ± 9.58	4.96 ± 1.12	5.6 ± 2.05

when compared with related parameters of control group 2.