Flavonoids Extraction from Propolis Attenuates Pathological Cardiac Hypertrophy through PI3K/AKT Signaling Pathway

Figure 4

FP treatment reduced associated disorder, such as fibrosis. (a) mRNA expression levels of the hypertrophy marker a-SKA and the fibrosis marker matrix metalloproteinase-9 (MMP-9). (b) Determination of fibrosis in histological sections by Masson’s trichrome staining. Scale bar, 50 μm. The arrows show fibrotic areas. The results are expressed as the means ± SE; mice per group ( compared with control group; compared with isoproterenol group).

(a)

(b)