Xianfanghuomingyin, a Chinese Compound Medicine, Modulates the Proliferation and Differentiation of T Lymphocyte in a Collagen-Induced Arthritis Mouse Model

Figure 2

Clinical scores of CIA, hematoxylin-eosin (HE) staining, Safranin O staining, and immunohistochemistry for IL-1β in metatarsophalangeal joints. (a) The clinical CIA scores monitored every 7 days after the booster immunization. Data are presented as means ± SD. compared to the normal group; , compared to the model group. (b) HE staining in metatarsophalangeal joints: ↑ indicates synovium, ▲ indicates articular cartilage, and indicates pannus. (c) Safranin O staining of the growth plate. The arrows indicate Safranin O staining. (d) Immunohistochemistry for IL-1β. The arrows indicate the location of IL-1β. Original magnification: 200x; (A) normal group, (B) model group, (C) group treated with LEF, and (D) group treated with XFHM. The scale bar corresponds to 60 μm throughout.

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