Evidence-Based Complementary and Alternative Medicine

Research Article

Xianfanghuomingyin, a Chinese Compound Medicine, Modulates the Proliferation and Differentiation of T Lymphocyte in a Collagen-Induced Arthritis Mouse Model

Table 1

Chemical components identified in xianfanghuomingyin by high performance liquid chromatography-electrospray ionization/mass.
NumberFragments ()FormulaIdentificationBiological activities
1 /152.0, 132.0 C8H8O4Vanillic acid Anti-inflammatory & immune-regulatory
2 321.1, 169.1 C16H24O10Loganic acid Anti-inflammatory & immune-regulatory
3 /135.0 C9H8O4Caffeic acid Inhibition on inflammatory proliferation
4 /173.0, 135.0 C16H18O9Chlorogenic acid Inhibition on inflammatory proliferation
5 195.1, 121.1 C16H20O9GentiopicrosideAnti-inflammatory & immune-regulatory
6 179.1, 151.1 C23H28O11PaeoniflorinAnti-inflammatory & immune-regulatory
7 179.1, 149.0 C17H26O10LoganinAnti-inflammatory & immune-regulatory
8 77.0, 105.1 C10H10O3Methyl 4-hydroxycinnamate Uncertain in autoimmune disease
9 /383.1, 473.1 C26H28O14ApiinAnti-inflammatory & immune-regulatory
10 307.1, 261.1 C22H28O11Prim-O-glucosylcimifuginAnti-inflammatory & immune-regulatory
11 /491.1, 271.0 C30H32O15GalloylpaeoniflorinUncertain in autoimmune disease
12 259.1, 235.1 C16H18O6CimifuginUncertain in autoimmune disease
13 /461.2, 161.0 C29H36O15ActeosideAnti-inflammatory & immune-regulatory
14 267.07 252.04 C22H22O9OnoninUncertainty in autoimmune disease
15 301.1, 167.1 C23H26O10LactiflorinUncertainty in autoimmune disease
16 220.1, 225.1 /268.0, 211.0 C16H12O5WogoninInhibition of inflammatory cell proliferation
17 270.1, 285.1 C22H20O11WogonosideInhibition for angiogenesis
18 /151.0, 119.1 C15H12O5NaringeninImmunostimulatory for dendritic cells
19 197.1, 226.1 /252.0, 223.0 C16H12O4FormononetinIncreased IL-4 production
20 /254.1, 210.1 C16H14O4IsoimperatorinAnti-inflammatory & immune-regulatory
21 /621.40, 651.41C41H68O14Astragaloside IVAnti-inflammatory & immune-regulatory