Evidence-Based Complementary and Alternative Medicine

Review Article

A Review of Western and Traditional Chinese Medical Approaches to Managing Nonalcoholic Fatty Liver Disease

Table 1

Fibrotic tests based on biochemical variables.


Test	Parameters	AUROC	Cutoffs	Sensitivity	Specificity	PPV	NPV

NAFLD fibrosis score [28]	IFG/DM, AST/ALT, age, BMI, PLT, albumin	0.82–0.88	<−1.455	77%	71%	52%	88%
NAFLD fibrosis score [28]	IFG/DM, AST/ALT, age, BMI, PLT, albumin		>0.676	43%	96%	82%	80%

FIB-4 [29, 45]	ALT, AST, PLT, age	0.80	<1.3	74%	71%	43%	90%
FIB-4 [29, 45]	ALT, AST, PLT, age	0.80	≥2.67	33%	98%	80%	83%

BARD [30]	BMI, AST/ALT, DM	0.81	2	—	—	43%	96%

APRI [29, 31]	AST, PLT	0.82	1.0	67%	81%	31%	95%

FibroMeter [31]	Glucose, ALT, AST, weight, age, PLT, ferritin	0.93–0.94		78%	96%	88%	92%

FibroTest [32]	Age, sex, bilirubin, GGT, apolipoprotein A1, haptoglobin, α2-macroglobulin	0.81–0.92	>0.3	92%	71%	33%	98%
FibroTest [32]			>0.7	25%		60%	89%

ALT: alanine aminotransferase; APRI: AST-to-platelet ratio; AST: aspartate aminotransferase; AUROC: area under receiver operating characteristic curve; BMI: body mass index; DM: diabetes mellitus; FIB-4: Fibrosis-4 test; GGT: γ-glutamyl transferase; IFG: impaired fasting glucose; NAFLD: nonalcohol fatty liver disease; NPV: negative predictive value; PLT: platelets; PPV: positive predictive value.