| | Type of study model | Experimental method [subject (age/weight), treatment dosage, duration of treatment] | Major activity | Mechanism of action | Reference |
| | In vivo study | CFD male New Zealand white rabbits (1500–2000 g) fed diet contain 3.75, 37.5, and 75 mg/kg of Mg, DSW 1410 hardness, 8 weeks | Reduced serum lipids, prevented atherogenesis, and suppressed serum cholesterol levels.
Reduced lipids accumulation in liver tissues, and limited aortic fatty streaks. | Improved protein expression of AMPK phosphorylation, ACC phosphorylation, and HMGCR. | [6] |
| | In vivo study | Male hyperlipidemia rabbits (1.8–2.0 g), DSW 1200 hardness, 150 ml/d, ad libitum, 12 weeks | Suppressed lipid deposition on the inner wall of the aorta. Suppressed foam cell formation.
| Reduced plasma TC, plasma LDL cholesterol, and LPO.
Increased plasma HDL cholesterol.
Increased glutathione peroxidase (GPx) activity.
Decreased plasma lipid peroxide (TBARS) value. | [21] |
| | In vivo study | CFD and hyperlipemia male Japanese rabbits, DSW hardness of 28, 300, and 1200, 150 ml/d, 4 weeks | Reduced TC and LDL-C levels in hyperlipemia rabbits.
Prevented increase of TC and LDL-C levels in CFD rabbits.
Reduced lipid accumulation in liver and permeation of macrophages in CFD rabbits. | ND. | [24] |
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