Involvement of 5-HT_1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System

Figure 1

Schematic illustration of the experimental design. The vehicle (control), quercitrin (2.5, 5.0, and 10.0 mg/kg), and diazepam (DZP, 2 mg/kg) were orally administered daily for 7 days. On the last day, the antagonists flumazenil (F; 3 mg/kg, i.p.) and WAY-100635 (W; 0.5 mg/kg, i.p.) were injected 15 min before the oral treatments. The behavioral tests (EPM, LDB, OFT, SP, and MB tests) were performed, and tissue samples were collected on the same day.