Involvement of 5-HT_1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System

Figure 2

Behavioral performance of mice in a 5 min session in the elevated plus maze performed 0.5 h after the injection of vehicle (control, p.o.), quercitrin (2.5, 5.0, and 10.0 mg/kg, p.o.), diazepam (DZP, 2 mg/kg, p.o.), flumazenil (F; 3 mg/kg, i.p., 15 min after p.o. administration of positive control or quercitrin, Q), and WAY-100635 (W; 0.5 mg/kg, i.p., 15 min before p.o. administration of quercitrin, Q). (a) Percentage of time spent in the open arms, (b) percentage of open arm entries, (c) percentage of time spent in the closed arms, (d) percentage of closed arm entries, and (e) percentage of time spent in central areas. Columns represent the means ± SEM; = 15 mice. and compared to the control group.

(a)

(b)

(c)

(d)

(e)