Involvement of 5-HT_1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System

Figure 3

Behavioral performance of mice in a 5 min session in the light and dark box performed 0.5 h after the injection of vehicle (control, p.o.), quercitrin (2.5, 5.0, and 10.0 mg/kg, p.o.), diazepam (DZP, 2 mg/kg, p.o.), flumazenil (F; 3 mg/kg, i.p., 15 min after p.o. administration of positive control or quercitrin, Q), and WAY-100635 (W; 0.5 mg/kg, i.p., 15 min before p.o. administration of quercitrin, Q). (a) Percentage of time spent in light compartment and (b) entries into the light box. Columns represent the means ± SEM; mice. and compared to the control group.

(a)

(b)