Research Article

Du-Huo-Ji-Sheng-Tang Attenuates Inflammation of TNF-Tg Mice Related to Promoting Lymphatic Drainage Function

Figure 1

Du-Huo-Ji-Sheng-Tang reduces inflammation and bone erosion in TNF-Tg mice. Three-month-old TNF-Tg mice were treated with Du-Huo-Ji-Sheng-Tang (12 g/kg/gavage, daily ×12 weeks) or saline. Ankle joints were harvested and subjected to histologic analysis. WT mice were included as control. (a) Representative HE-stained sections show decreased inflammation and bone loss in the Du-Huo-Ji-Sheng-Tang-treated joints. Bar, 200 μm, black arrow indicates inflammatory synovial tissue. Quantitation of bone area (b) and inflammatory synovial area (c). Values are the mean ± SD of 6–8 legs per group. versus WT; versus TNF-Tg + saline.
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