Randomized, Double-Blinded, Double-Dummy, Active-Controlled, and Multiple-Dose Clinical Study Comparing the Efficacy and Safety of Mulberry Twig (Ramulus Mori, Sangzhi) Alkaloid Tablet and Acarbose in Individuals with Type 2 Diabetes Mellitus
Table 3
Adverse events.
SZ-A ()
Acarbose ()
Overall treatment withdrawal rate
2 (0.09%)
0
Treatment withdrawal due to adverse event
0
0
Participants with serious adverse event
0
0
Adverse event
Gastrointestinal disorders
1 (4.76%)
5 (33.33%)
Increased release of gas
1 (4.76%)
2 (13.33%)
Diarrhea
0
3 (20%)
Abdominal pain
0
0
Dyspepsia
0
0
Flatulence
0
0
Urinary tract infection
2 (9.52%)
0
Increased alanine aminotransferase (mild)
2 (9.52%)
0
Increased aspartate aminotransferase (mild)
1 (4.76%)
0
Reduced creatinine clearance (mild)
1 (4.76%)
0
Increased urine acid
1 (4.76%)
0
ECG changes from normal
Sinus bradycardia
1 (4.76%)
0
T wave nonspecific changes
1 (4.76%)
0
ST segment ischemic changes
1 (4.76%)
0
No deaths were reported in the trial period (weeks 0–24). One patient’s alanine aminotransferase was normal on further testing until end of treatment. This patient’s aspartate aminotransferase was normal on further testing until end of treatment. This patient was lost to follow-up.
