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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 7242478, 7 pages
Review Article

Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-Analysis

1The First Clinical College, Jinan University and Department of Orthopedics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China
2The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
3Department of Orthopedics, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
4Department of Orthopedics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
5Department of Orthopedics, Guangzhou Orthopedic Hospital, Guangzhou 510045, China
6Department of Orthopedics, Xingtai People’s Hospital, Xingtai, Hebei 054031, China

Received 11 April 2016; Accepted 27 June 2016

Academic Editor: Antonella Fioravanti

Copyright © 2016 Huajun Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Studies revealed that metabolic factors might contribute substantially to osteoarthritis (OA) pathogenesis. There has been an increasing interest to understand the relationship between knee OA and the metabolic syndrome (MetS). The purpose of this study was to explore the association between metabolic syndrome and knee osteoarthritis using meta-analysis. Methods. Databases, including PUBMED, EMBASE, and the Cochrane Library, were searched to get relevant studies. Data were extracted separately by two authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Results. The meta-analysis was finished with 8 studies with a total of 3202 cases and 20968 controls finally retrieved from the database search. The crude pooled OR is 2.24 (95% CI = 1.38–3.64). Although there was significant heterogeneity among these studies, which was largely accounted for by a single study, the increase in risk was still significant after exclusion of that study. The pooled adjusted OR remained significant with pooled adjusted OR 1.05 (95% CI = 1.03–1.07, ). No publication bias was found in the present meta-analysis. Conclusions. The synthesis of available evidence supports that metabolic syndrome increases the risk for knee osteoarthritis, even after adjustment for many risk factors.