A Fomitopsis pinicola Jeseng Formulation Has an Antiobesity Effect and Protects against Hepatic Steatosis in Mice with High-Fat Diet-Induced Obesity

Figure 5

Effect of FAVA on hepatic steatosis and mRNA expressions of cholesterol biosynthesis in the liver of mice. (a) Hematoxylin and eosin staining of liver from mice fed chow diet (CHOW), high-fat diet (HFD), or high-fat diet supplemented with orlistat at 60 mg/kg/day (HFD + ORLISTAT) or high-fat diet supplemented with FAVA at 200 mg/kg/day (HFD + FAVA) (40x magnification). ((b)–(d)) The graphs represent mRNA expression of cholesterol synthesis factors AACS (b), HMGCR (c), and SREBP2 (d), which was analyzed by real-time PCR. The data represent the mean ± SEM ( and versus the CHOW group; and versus the HFD group, ).

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