Unsweetened Natural Cocoa Powder Has the Potential to Attenuate High Dose Artemether-Lumefantrine-Induced Hepatotoxicity in Non-Malarious Guinea Pigs

Figure 10

A representation of sections of liver from guinea pigs that received (a) only a 3-day HD A/L administration (75 mg/kg/bwt) showing disturbed (necrotic) liver parenchyma (NeLP), a highly congested and dilated central vein (CCV), and lymphocytic infiltration (LYM). (b) Distilled water (control) showing undisturbed liver parenchyma (NoLP) with uncongested central veins (UCV). Note the regularity of liver cell plates, microcirculatory zones, and sinusoids. (c) A 14-day UNCP administration (300 mg/kg/bwt) followed by a 3-day A/L administration (75 mg/kg/bwt) showing undisturbed liver parenchyma with an uncongested but dilated central vein (DCV). (d) A 14-day UNCP administration (900 mg/kg/bwt) followed by a 3-day A/L administration (75 mg/kg/bwt) showing undisturbed liver parenchyma with an uncongested but dilated central vein (DCV). (e) A 14-day UNCP administration (1500 mg/kg/bwt) followed by a 3-day A/L administration (75 mg/kg/bwt) showing undisturbed liver parenchyma with an uncongested but dilated central vein (DCV) (H & E stain ×40).

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