Natural Products Improving Hyperuricemia with Hepatorenal Dual Effects

Table 1

The hepatorenal dual actions of natural products on hyperuricemia.

Natural products	Inhibition of the generation	Inhibition of the absorption	Promote the secretion	Refs.
Longan seed extract (LSE)	Inhibit activity of XOD/ADA	Decrease GLUT9 but increase GLUT1	None	[15]
Plantago asiatica L. herbs extracts (PAHEs)	Inhibit activity of XOD	Downregulate renal URAT1	None	[16]
Bergenin	Inhibit activity of XOD	Downregulate URAT1 and GLUT9	None	[17]; [18]
Sea cucumber saponin	Inhibit activity of XOD/ADA	Downregulate GLUT9	None	[19]
Sea cucumber polysaccharides	Inhibit activity of XOD/ADA; Downregulate XOD/ADA	Downregulate GLUT9	None	[19]
Puerarin	Inhibit activity of XOD	Unidentified	Unidentified	[20]
Total saponins from Rhizoma Dioscoreae Nipponicae	Inhibit activity of XOD/ADA	None	Upregulate OAT1	[21]
Sea cucumber saponin-EA	Inhibit activity of XOD/ADA	None	Upregulate OAT1	[19]
Jasminoidin	Inhibit activity of XOD	Regulate expressions of renal urate transporters	None	[22]
Green tea polyphenols	Reduce XOD expression	Reduce URAT1	Upregulate OAT1 and OAT3	[23]
Smilax riparia A. D. C	Inhibit activity of XOD	Downregulate renal URAT1 and GLUT9	Upregulate OAT1	[24]
Modified Simiao Decoction	Inhibit activity of XOD	Downregulate URAT1	Upregulate OAT1	[25]
Total saponins of Dioscorea	Inhibit activity of XOD	Downregulate URAT1	Upregulate OAT1 and OAT3	[26]
Lagotis brevituba Maxim. (LBM) extracts	Inhibit activity of XOD	Downregulate renal; URAT1 and GLUT9	Upregulate OAT1	[27]
P. sibircum Laxm. alcohol extract 2.0/4.0/8.0 g/kg	Inhibit activity of XOD	Reduce GLUT9	Upregulate OAT1	[28]
P. sibircum Laxm. alcohol extract 8.0 g/kg	Inhibit activity of XOD	Reduce URAT1 and GLUT9	Upregulate OAT1	[28]