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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 7480971, 10 pages
http://dx.doi.org/10.1155/2016/7480971
Research Article

The Fruit Hull of Gleditsia sinensis Enhances the Anti-Tumor Effect of cis-Diammine Dichloridoplatinum II (Cisplatin)

1School of Korean Medicine, Pusan National University, Yangsan 50621, Republic of Korea
2Department of Internal Medicine, Korean Medicine Hospital of Pusan National University, Yangsan 50621, Republic of Korea
3Lung Cancer Clinic, Pulmonary Medicine Center, Pusan National University Yangsan Hospital, Yangsan 50621, Republic of Korea
4Department of Internal Medicine, School of Medicine, Pusan National University, Yangsan 50621, Republic of Korea
5Department of Acupuncture and Moxibustion, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea

Received 26 May 2016; Accepted 18 August 2016

Academic Editor: Siyaram Pandey

Copyright © 2016 Kyun Ha Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Lung cancer has substantial mortality worldwide, and chemotherapy is a routine regimen for the treatment of patients with lung cancer, despite undesirable effects such as drug resistance and chemotoxicity. Here, given a possible antitumor effect of the fruit hull of Gleditsia sinensis (FGS), we tested whether FGS enhances the effectiveness of cis-diammine dichloridoplatinum (II) (CDDP), a chemotherapeutic drug. We found that CDDP, when administered with FGS, significantly decreased the viability and increased the apoptosis and cell cycle arrest of Lewis lung carcinoma (LLC) cells, which were associated with the increase of p21 and decreases of cyclin D1 and CDK4. Concordantly, when combined with FGS, CDDP significantly reduced the volume and weight of tumors derived from LLC subcutaneously injected into C57BL/6 mice, with concomitant increases of phosphor-p53 and p21 in tumor tissue. Together, these results show that FGS could enhance the antitumor activity of CDDP, suggesting that FGS can be used as a complementary measure to enhance the efficacy of a chemotherapeutic agent such as CDDP.