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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 7515413, 11 pages
Review Article

The Efficacy of Shen Shuaining Capsule on Chronic Kidney Disease: A Systematic Review and Meta-Analysis

1First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210029, China
2Chinese Medicine Department, Zhongda Hospital Southeast University, Nanjing 210000, China
3Famous Doctor’s Studio of Zhongying Zhou, Nanjing University of Chinese Medicine, Nanjing 210029, China

Received 7 September 2015; Revised 3 January 2016; Accepted 11 January 2016

Academic Editor: Caigan Du

Copyright © 2016 Shanshan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To evaluate the efficacy of Shen shuaining capsule on treating chronic kidney disease (CKD). Methods. All randomized controlled trials (RCTs) of Shen shuaining capsule in treating CKD were collected from CBM, CNKI, VIP, Wanfang, EMBASE, MEDLINE, PubMed, and Cochrane library clinical controlled trials database. Two reviewers independently performed analysis of the included trials according to the inclusion and exclusion criteria. The risk of bias tool was from the Cochrane Handbook version 5.1.0. The Review Manager 5.2 software was employed for data analysis. Funnel plot and Egger’s test were applied to evaluate publication bias. Results. 20 studies including 1606 participants met the inclusion criteria, most of which were of low quality. Meta-analysis indicated that Shen shuaining capsule was effective for CKD in terms of SCR, BUN, Hb, and response rate and with less adverse effects, of which SCR and BUN decreased significantly (MD = −84.72, 95% CI: −107.36, −62.07, ) (MD = −4.30, 95% CI: −5.71, −2.89, ); Hb and response rate increased significantly (MD = 9.94, 95% CI: 9.24, 10.64, ) (OR = 4.25, 95% CI (3.32, 5.42), ). Conclusion. Shen shuaining capsule significantly reduced SCR and BUN, increased HB, and improved total efficiency of the symptoms and signs in patients with CKD. Subgroup analysis found that Shen shuaining capsule group was better than control group. Due to low quality of the methodology of included studies, further high-quality researches were needed to study its efficacy and safety.