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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 7603975, 10 pages
http://dx.doi.org/10.1155/2016/7603975
Research Article

Improvement of Electroacupuncture on APP/PS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of Aβ and LRP1 in Hippocampus

1School of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, No. 11 Bei San Huan Dong Lu, Chaoyang District, Beijing 100029, China
2Community Health Service Administration Center of Dongcheng District, No. 192-1 Chaoyangmen Internal Street, Dongcheng District, Beijing 100053, China

Received 3 June 2016; Revised 22 August 2016; Accepted 5 September 2016

Academic Editor: Genevieve Steiner

Copyright © 2016 Xin Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To explore the alterations of β-amyloid (Aβ) and low density lipoprotein receptor-related protein-1 (LRP1) in APP/PS1 mice after electroacupuncture (EA) treatment and further to explore the mechanism. Methods. Forty 6-month-old APP/PS1 mice were randomly divided into a model group and an EA group, with twenty wild-type mice used as a normal control group. Mice in the EA group were treated with EA at GV 20 (băi huì) and bilateral KI 1 (yŏng quán) acupoints for 6 weeks. The Morris water maze was applied to assess the spatial memory in behavior. Immunohistochemistry (IHC), ELISA, Western blotting, and so forth were used to observe the expression of LRP1 and Aβ. Results. The Morris water maze test showed that, compared with the normal control group, the model group’s learning and memory capabilities were significantly decreased (; ). The EA group was reversed (; ). The hippocampal expression of Aβ in the EA group was significantly decreased compared to the model group (). The expression of LRP1 in the model group was significantly lower than that in the normal control group (); the expression in the EA group was significantly higher than that in the model group (). Conclusions. EA therapy can improve the learning and memory capabilities of APP/PS1 mice. The underlying mechanism may lie in the upregulation of an Aβ transport receptor and LRP1.