Research Article
Improvement of Electroacupuncture on APP/PS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of Aβ and LRP1 in Hippocampus
Figure 4
Laser confocal imaging of Aβ1–42 and LRP1 in hippocampus (original magnification ×600): (A) stack imaging of the three; (B) imaging of cell nucleus; (C) LRP1 labeled with green fluorescence; (D) Aβ1–42 labeled with red fluorescence; (a) in normal control group, plaque deposits of Aβ1–42 were not found, while LRP1 was expressed mostly around the vascular endothelial cells; (b) in model group, there were dense-core plaques deposited, while less LRP1 was expressed; (c) in EA group, the senile plaques were relatively reduced, and there were only some diffuse plaques, while the expression of LRP1 was more than that of model group.
| (a) Normal control group (C) |
| (b) Model group (M) |
| (c) EA group (EA) |