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Evidence-Based Complementary and Alternative Medicine
Volume 2016 (2016), Article ID 7638542, 8 pages
http://dx.doi.org/10.1155/2016/7638542
Research Article

Germinated and Ungerminated Seeds Extract from Two Lupinus Species: Biological Compounds Characterization and In Vitro and In Vivo Evaluations

1Department of Orthopedics, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square, No. 2, 300041 Timişoara, Romania
2Department of Pharmacognosy, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square, No. 2, 300041 Timişoara, Romania
3Department of Food Control, Banat’s University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timisoara, Calea Aradului No. 119, 300641 Timisoara, Romania
4Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, Szeged 6720, Hungary
5Department of Microbiology-Virology, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square, No. 2, 300041 Timişoara, Romania
6Department of Pathology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
7Department of Toxicology, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square, No. 2, 300041 Timişoara, Romania
8Department of Pharmaceutical Chemistry, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square, No. 2, 300041 Timişoara, Romania
9Department of Pharmacology and Pharmacy, Banat’s University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timisoara, Calea Aradului No. 119, 300641 Timisoara, Romania

Received 21 July 2016; Revised 2 November 2016; Accepted 17 November 2016

Academic Editor: José L. Ríos

Copyright © 2016 Bogdan Andor et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In recent years, nutraceuticals attracted a great amount of attention in the biomedical research due to their significant contribution as natural agents for prevention of various health issues. Ethanolic extracts from the ungerminated and germinated seeds of Lupinus albus L. and Lupinus angustifolius L. were analyzed for the content in isoflavones (genistein) and cinnamic acid derivatives. Additionally, the extracts were evaluated for antimicrobial, antiproliferative, and anti-inflammatory properties, using in vitro and in vivo tests. Germination proved to be a method of choice in increasing the amount of genistein and cinnamic acid derivatives in both Lupinus albus L. and Lupinus angustifolius L. seeds. Biological evaluation of all vegetal extracts revealed a weak therapeutic potential for both ungerminated and germinated seeds.