A 70% Ethanol Extract of Mistletoe Rich in Betulin, Betulinic Acid, and Oleanolic Acid Potentiated β-Cell Function and Mass and Enhanced Hepatic Insulin Sensitivity

Figure 2

Insulin secretion capacity during hyperglycemic clamp. At the end of the experimental periods, hyperglycemic clamp was performed on Px rats fed high-fat diets supplemented with either (1) 0.6% water extract of Korean mistletoe (KMW-W), (2) 0.6% of 70% ethanol extract of Korean mistletoe (KME-E), or (3) 0.6% dextrose (Px-control). As a normal-control group, sham-operated rats were provided with a high-fat diet containing 0.6% dextrose. During hyperglycemic clamp, serum insulin levels were measured in free-moving and overnight-fasted diabetic rats as serum glucose levels at 5.5 mM above fasting levels were maintained. The sample size in each group was the same as in Table 3. The dots and error bars represent mean ± SD. different among the groups in one-way ANOVA at a significance of .