A 70% Ethanol Extract of Mistletoe Rich in Betulin, Betulinic Acid, and Oleanolic Acid Potentiated β-Cell Function and Mass and Enhanced Hepatic Insulin Sensitivity

Table 4

The modulation of islet morphometry at the end of experiment.

	Control ()	KME-W ()	KME-E ()	Normal-control ()
β-cell area (%)	7.5 ± 0.9	7.7 ± 0.8	8.7 ± 0.9	6.3 ± 0.7
Individual β-cell size (μm^2)	242 ± 30	193 ± 25	201 ± 24	189 ± 23
Absolute β-cell mass (mg)	32.3 ± 3.4	33.5 ± 3.7	39.8 ± 4.0	57.3 ± 6.2
BrdU^+ cells (% BrdU^+ cells of islets)	0.97 ± 0.13	1.01 ± 0.13	1.14 ± 0.15	0.75 ± 0.11
Apoptosis (% apoptotic bodies of islets)	1.08 ± 0.12	0.92 ± 0.09	0.88 ± 0.12	0.73 ± 0.08

Values are mean ± SD. Diabetic Px rats were provided with high-fat diets supplementing (1) 0.6% water extract of Korean mistletoe (KMW-W), (2) 0.6% of 70% ethanol extract (KME-E), or (3) 0.6% dextrose (Control). Sham-operated rats were provided with a high-fat diet containing 0.6% dextrose as a normal-control.
Values in the same row with different superscripts were significantly different in Tukey test at .