Electroacupuncture Alleviates Depressive-Like Symptoms and Modulates BDNF Signaling in 6-Hydroxydopamine Rats

Figure 1

Effects of 100 Hz EA treatment on motor symptoms and dopaminergic neurodegeneration in the ventral midbrain of 6-OHDA lesioned rats. ((a)–(c)) Effects of EA on APO-induced rotational behavior (a), rotarod test (b), and horizontal movement distance in the open field test (c). Data represent mean ± SEM ( = 9–11 per group). and versus the sham group; versus the model group. (d) Effects of EA on TH immunohistochemical staining. SNc is implied by the elliptical dotted line and VTA is implied by rectangle dotted line in (d). ((e) and (f)) Quantification of the damaged extent of TH-positive profiles on lesioned compared to unlesioned side in the SNc (e) and in the VTA (f). Data represent mean ± SEM, , and versus the sham group.

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