Traditional Preparations and Methanol Extracts of Medicinal Plants from Papua New Guinea Exhibit Similar Cytochrome P450 Inhibition

Table 1

CYP inhibition across methanol (M) and succus (S) studies.

Genus and species	M/S	CYP1A2; % inhibition		Inh?; (Y/N)	CYP3A4; % inhibition		Inh?; (Y/N)	CYP2D6; % inhibition		Inh?; (Y/N)
		MR (2.0 μM)	MR (0.4 μM)		7-BQ (500 μM)	7-BQ (100 μM)		MAMC (100 μM)	MAMC (40 μM)
Bidens pilosa (Asteraceae)	M	—	—	N^#	—	—	N^#	—	—	N^#
Bidens pilosa (Asteraceae)	M	—	—	N^#	—	—	N^#	—	51	Y^†
Bidens pilosa (Asteraceae)	S	—	—	N^##	—	—	N^##	—	—	N^##
Calophyllum inophyllum (Calophyllaceae)	M	74	86	Y^†	—	79	Y^†	52	60	Y^†
Calophyllum inophyllum (Calophyllaceae)	S	61	86	Y^‡	—	79	Y^‡	70	—	Y^‡
Cassia alata (Fabaceae)	M	—	54	Y^†	—	—	N^#	56	61	Y^†
Cassia alata (Fabaceae)	M	58	75	Y^†	—	57	Y^†	54	—	Y^†
Cassia alata (Fabaceae)	S	—	58	Y^‡	—	62	Y^‡	50	83	Y^‡
Casuarina equisetifolia (Casuarinaceae)	M	66	65	Y^†	54	61	Y^†	—	54	Y^†
Casuarina equisetifolia (Casuarinaceae)	S	70	80	Y^‡	—	74	Y^‡	—	—	N^##
Eleusine indica (Poaceae)	M	—	—	N^#	—	—	N^#	—	—	N^#
Eleusine indica (Poaceae)	M	—	—	N^#	—	—	N^#	—	—	N^#
Eleusine indica (Poaceae)	S	—	—	N^##	—	—	N^##	—	—	N^##
Ficus wassa (Moraceae)	M	—	—	N^#	—	—	N^#	—	—	N^#
Ficus wassa (Moraceae)	S	—	—	N^##	—	—	N^##	—	—	N^##
Hibiscus rosa-sinensis (Malvaceae)	M	—	—	N^#	—	—	N^#	—	—	N^#
Hibiscus rosa-sinensis (Malvaceae)	S	—	—	N^##	—	—	N^##	—	—	N^##
Hibiscus tiliaceus (Malvaceae)	M	—	—	N^#	—	—	N^#	—	—	N^#
Hibiscus tiliaceus (Malvaceae)	S	—	—	N^##	—	—	N^##	—	—	N^##
Ipomoea pes-caprae (Convolvulaceae)	M	56	69	Y^†	58	60	Y^†	—	—	N^#
Ipomoea pes-caprae (Convolvulaceae)	S	—	—	N^##	—	70	Y^‡	—	—	N^##
Laportea decumana (Urticaceae)	M	—	—	N^#	—	—	N^#	—	—	N^#
Laportea decumana (Urticaceae)	S	—	—	N^##	—	—	N^##	—	—	N^##
Morinda citrifolia (Rubiaceae)	M	—	—	N^#	—	—	N^#	—	—	N^#
Morinda citrifolia (Rubiaceae)	S	—	56	Y^‡	—	—	N^##	—	—	N^##
Morinda citrifolia (Rubiaceae)	S	—	—	N^##	—	—	N^##	—	—	N^##
Passiflora foetida (Passifloraceae)	M	—	—	N^#	—	51	Y^†	—	—	N^#
Passiflora foetida (Passifloraceae)	S	—	52	Y^‡	—	59	Y^‡	—	52	Y^‡
Passiflora foetida (Passifloraceae)	S	—	64	Y^‡	—	69	Y^‡	55	62	Y^‡
Premna obtusifolia (Verbenaceae)	M	53	68	Y^†	—	—	N^#	—	—	N^#
Premna obtusifolia (Verbenaceae)	S	—	—	N^##	—	—	N^##	—	—	N^##
Sida rhombifolia (Malvaceae)	M	54	75	Y^†	—	—	N^#	—	—	N^#
Sida rhombifolia (Malvaceae)	S	—	—	N^##	—	60	Y^‡	—	—	N^##
Terminalia catappa (Combretaceae)	M	96	92	Y^†	64	80	Y^†	67	81	Y^†
Terminalia catappa (Combretaceae)	S	84	76	Y^‡	73	87	Y^‡	55	68	Y^‡

Inhibition indicated by “†” (for M study) and“‡” (for S study). No inhibition indicated by “#” (for M study) and“##” (for S study).
(—) activity was <50% inhibition.