Preventive Effect of Dihydromyricetin against Cisplatin-Induced Nephrotoxicity In Vitro and In Vivo

Figure 5

Dihydromyricetin decreased PMN infiltration and expression of several proinflammatory cytokines. (a) Hematoxylin and eosin (HE) staining was performed for the analysis of PMN infiltration. Scale bar, 50 μm. (b) The semiquantitative score of PMN infiltration was measured according to Section 2. (c) q-PCR analysis of IL-1β, IL-6, TNF-α, and MCP-1 mRNA expression in the nondrug treatment group, DMY treatment group, cisplatin treatment group, and cisplatin with DMY (500 mg/kg) treatment group (). Data are presented as mean ± SD. versus cisplatin treatment group, versus cisplatin treatment group.

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