Effect of Heweianshen Decoction on Orexin-A and Cholecystokinin-8 Expression in Rat Models of Insomnia

Table 1

Effect of the Heweianshen decoction on behavioral activities of rat model of insomnia ().

Group		Walking time (s)		Forelimb lifting-up frequency
		Before treatment	After treatment	Before treatment	After treatment
Blank group	10	129.25 ± 4.21	130.24 ± 4.53	15.16 ± 1.26	16.36 ± 1.57
PCPA model group	10	159.47 ± 5.46	160.15 ± 5.37	24.32 ± 1.24	25.18 ± 1.72
Low-dose group	10	156.33 ± 6.11	146.38 ± 5.72	25.12 ± 2.01	21.93 ± 2.18
Medium-dose group	10	158.21 ± 5.82	139.25 ± 4.58	24.83 ± 1.67	19.62 ± 1.81
High-dose group	10	160.15 ± 5.36	135.42 ± 4.61	24.75 ± 1.76	17.24 ± 2.31

Notes: blank group and model group were given normal saline 1 mL/100 g; the low-, medium-, and high-dose HAD-treated groups were given Heweianshen decoction of 5.25, 10.5, and 21 g⋅kg⁻¹⋅d⁻¹, respectively. Compared with before treatment, ; compared with the blank group, ; compared with the model group, .