Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats

Figure 4

Effects of PF and AF on the elevated proinflammatory cytokines (TNF-α, IL-β, and IL-6) and chemokine CXCL1 levels in the spinal card dorsal horn of CCI rats. After treatment with PF for 15 days following CCI, the levels of IL-β (a), IL-6 (b), TNF-α (c), and CXCL1 (d) were measured by enzyme-linked immunosorbent assay; scale bar = 100 μm. Data were expressed as mean ± SE and rats/group. , , and compared with the Sham group. and compared with the CCI group.

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