Glycyrrhizic Acid Attenuates Sepsis-Induced Acute Kidney Injury by Inhibiting NF-κB Signaling Pathway

Figure 4

GA inhibited the productions of NO and PGE₂ and expressions of iNOS and COX-2 in kidney tissue induced by AKI. (a) The amount of nitrite in the kidney tissue was detected by the Griess Reagent System. (b) The concentration of PGE₂ in kidney from different groups. The expression of iNOS in kidney was measured by immunohistochemical staining (magnification 400x) (b) and western blot (c). The expression of COX-2 in kidney was measured by immunohistochemical staining (magnification 400x) (d) and western blot (e). The results shown are representative of at least three independent experiments. Each value represents the mean ± SD (). , versus the sham operation group. ^#; ^##; ^###, versus the sepsis group.

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