Table 1: Sixteen bioactive components and their regulated TFs and DEGs.

TCMTZS componentsThe CID of
component that interacts with TF
Tanimoto coefficientTFDifferential expression genes

Gastrodia elata BL.4,4′-Dihydroxydiphenyl methane66230.877023ER-alphaF5/Hba-a2/Rnase111
β-Sitosterol23710.915282Sp1Rnase4/F5/Slc19a3
25240.896709Egr-1Ifitm7
Citric acid3111Olf-1Cyp2a2/Cyp2j4
3-Hydroxy-3-methoxycarbonylpentanedioic acid3110.8Olf-1Cyp2a2/Cyp2j4
Daucosterol23710.879428Sp1Rnase4/F5/Slc19a3
25240.852015Egr-1Ifitm7
Margaric acid9850.994764Sp1Rnase4/F5/Slc19a3
25060.941581Sp1Rnase4/F5/Slc19a3
1481770.875424Sp1Rnase4/F5/Slc19a3
Bis(4-Hydroxybenzyl)ether66230.850932ER-alphaF5/Hba-a2/Rnasel11
Vitamin A55380.970093c-FosDusp12/Gpatch4/Ngf/Nts/Hba-a2/RGD1564469
17440.856672CHOP-10Ttr/Kcnj13
Palmitic acid9851Sp1Rnase4/F5/Slc19a3
25060.933009Sp1Rnase4/F5/Slc19a3
Palmitoyl glycerol25060.96445Sp1Rnase4/F5/Slc19a3
9850.94697Sp1Rnase4/F5/Slc19a3
39870.916115Egr-1Ifitm7
1481770.884291Sp1Rnase4/F5/Slc19a3
24990.852916STAT5BClic6

Trillium tschonoskii Maxim.Pennogenin25240.890232Egr-1Ifitm7
23710.882143Sp1Rnase4/F5/Slc19a3
544540.863784ATF-2Cyp2j4/Rasl11a/Slc16a13
Linoleic acid14240.932432RelACyp2j4/RT1-T24-4/Nqo2
39870.865169Egr-1Ifitm7
14440.860317STAT3Clic6/Hbb/Krt18/Fpr-rs3/Ifitm7/RGD1564126/Zfp467
4-Hydroxybenzoic acid445403570.8679c-JunDusp12/Gpatch4/Ngf/Fpr-rs3/Hba-a2/RGD1564469/S100vp
3-O--L-Rhamnopyranosyl (13) sterylglucoside23710.879428Sp1Rnase4/F5/Slc19a3
25240.852015Egr-1Ifitm7
26-Chloro-26-deoxycryptogenin23710.886708Sp1Rnase4/F5/Slc19a3
25240.878365Egr-1Ifitm7
1468980.862239STAT2Clic6/Naip5/Cyp11b3
544540.855305ATF-2Cyp2j4/Rasl11a/Slc16a13
4007690.853801STAT3Clic6/Hbb/Krt18/Fpr-rs3/Ifitm7/RGD1564126/Zfp467
57530.853659FOXO3Fpr-rs3/RGD1559708
Diosgenin23710.885714Sp1Rnase4/F5/Slc19a3
25240.881Egr-1Ifitm7
544540.866091ATF-2Cyp2j4/Rasl11a/Slc16a13

The Tanimoto coefficient of these components was greater than 0.85; this table shows the corresponding relationship between the bioactive components, TFs and DEGs.