Evidence-Based Complementary and Alternative Medicine / 2016 / Article / Tab 1 / Research Article
ITPI: Initial Transcription Process-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula Table 1 Sixteen bioactive components and their regulated TFs and DEGs.
TCM TZS components The CID of component that interacts with TF Tanimoto coefficient TF Differential expression genes Gastrodia elata BL.4,4′-Dihydroxydiphenyl methane 6623 0.877023 ER-alpha F5 /Hba-a2 /Rnase111 β -Sitosterol2371 0.915282 Sp1 Rnase4 /F5 /Slc19a3 2524 0.896709 Egr-1 Ifitm7 Citric acid 311 1 Olf-1 Cyp2a2 /Cyp2j4 3-Hydroxy-3-methoxycarbonylpentanedioic acid 311 0.8 Olf-1 Cyp2a2 /Cyp2j4 Daucosterol 2371 0.879428 Sp1 Rnase4 /F5 /Slc19a3 2524 0.852015 Egr-1 Ifitm7 Margaric acid 985 0.994764 Sp1 Rnase4 /F5 /Slc19a3 2506 0.941581 Sp1 Rnase4 /F5 /Slc19a3 148177 0.875424 Sp1 Rnase4 /F5 /Slc19a3 Bis(4-Hydroxybenzyl)ether 6623 0.850932 ER-alpha F5 /Hba-a2 /Rnasel11 Vitamin A 5538 0.970093 c-Fos Dusp12 /Gpatch4 /Ngf /Nts /Hba-a2 /RGD1564469 1744 0.856672 CHOP-10 Ttr /Kcnj13 Palmitic acid 985 1 Sp1 Rnase4 /F5 /Slc19a3 2506 0.933009 Sp1 Rnase4 /F5 /Slc19a3 Palmitoyl glycerol 2506 0.96445 Sp1 Rnase4 /F5 /Slc19a3 985 0.94697 Sp1 Rnase4 /F5 /Slc19a3 3987 0.916115 Egr-1 Ifitm7 148177 0.884291 Sp1 Rnase4 /F5 /Slc19a3 2499 0.852916 STAT5B Clic6 Trillium tschonoskii Maxim.Pennogenin 2524 0.890232 Egr-1 Ifitm7 2371 0.882143 Sp1 Rnase4 /F5 /Slc19a3 54454 0.863784 ATF-2 Cyp2j4 /Rasl11a /Slc16a13 Linoleic acid 1424 0.932432 RelA Cyp2j4 /RT1-T24-4 /Nqo2 3987 0.865169 Egr-1 Ifitm7 1444 0.860317 STAT3 Clic6 /Hbb /Krt18 /Fpr-rs3 /Ifitm7 /RGD1564126 /Zfp467 4-Hydroxybenzoic acid 44540357 0.8679 c-Jun Dusp12 /Gpatch4 /Ngf /Fpr-rs3 /Hba-a2 /RGD1564469 /S100vp 3-O- -L-Rhamnopyranosyl (1 3) sterylglucoside 2371 0.879428 Sp1 Rnase4 /F5 /Slc19a3 2524 0.852015 Egr-1 Ifitm7 26-Chloro-26-deoxycryptogenin 2371 0.886708 Sp1 Rnase4 /F5 /Slc19a3 2524 0.878365 Egr-1 Ifitm7 146898 0.862239 STAT2 Clic6 /Naip5 /Cyp11b3 54454 0.855305 ATF-2 Cyp2j4 /Rasl11a /Slc16a13 400769 0.853801 STAT3 Clic6 /Hbb /Krt18 /Fpr-rs3 /Ifitm7 /RGD1564126 /Zfp467 5753 0.853659 FOXO3 Fpr-rs3 /RGD1559708 Diosgenin 2371 0.885714 Sp1 Rnase4 /F5 /Slc19a3 2524 0.881 Egr-1 Ifitm7 54454 0.866091 ATF-2 Cyp2j4 /Rasl11a /Slc16a13
The Tanimoto coefficient of these components was greater than 0.85; this table shows the corresponding relationship between the bioactive components, TFs and DEGs.