Evidence-Based Complementary and Alternative Medicine

Review Article

Assessment of the Therapeutic Effect of Total Glucosides of Peony for Juvenile Idiopathic Arthritis: A Systematic Review and Meta-Analysis

Table 1

Characteristic of included studies.


Study	Case number (I/C)	Age (years)	Sex (male/female)	Subtype of JIA	Intervention (I)	Control (C)	Outcomes	Duration

Shi and Ding (2004) [24]	18/13	Unclear	Unclear	Unclear	TGP 0.9 g/d, oral.	MTX 10 mg/m²/w, oral	Overall response rate, AE	6 W, 24 W

Tang et al. (2004) [25]	16/16	9.5	17/15	Unclear	TGP 30–60 mg/kg/d, oral. Naproxen 10–12 mg/kg/d, prednisone 1-2 mg/kg/d, oral.	Naproxen 10–12 mg/kg/d, prednisone 1-2 mg/kg/d, oral	Overall response rate, autoantibody	2 M

Zang (2004) [26]	42/26	8.6 (3–14)	32/36	Poly 34, Pauci 18, and systemic 16	TGP 0.03–0.06 g/kg/d, oral.	MTX 0.2–0.4 mg/kg/w, oral	Overall response rate, ESR, CRP, DMS, prednisone dosage, prednisone treatment duration, pain score, and AE	6 M

Cao et al. (2006) [27]	40/40	9.5 ± 3.0	52/28	Pauci 25, poly 11, and systemic 44	TGP 0.018 g/kg, twice a day orally; MTX 10 mg/m² and folic acid 5 mg, once a week orally.	MTX 10 mg/m² and folic acid 5 mg, once a week orally	Overall response rate, AE	8 W, 24 W

Li et al. (2008) [28]	18/18	7.1 ± 2.6	Unclear	Unclear	TGP 0.015 g/kg, twice a day orally, MTX 10 mg/m², and folic acid 5 mg, once a week orally.	MTX 10 mg/m² and folic acid 5 mg, once a week orally	ESR, CRP, DMS, TJC, and SJC	8 W, 12 W

Liu (2008) [29]	35/35	8.6	41/29	Systemic 70	TGP + MTX, oral dose (unclear).	MTX, oral dose (unclear)	Overall response rate, CRP, ESR, prednisone dosage, and prednisone treatment duration	6 M

Tong and Shui (2009) [30]	42/42	3–15	38/46	Unclear	TGP 15–30 mg/kg, twice a day orally, Lef 0.2–0.4 mg/kg, and Mel 5–7.5 mg, once a week orally.	Lef 0.2–0.4 mg/kg, Mel 5–7.5 mg, once a week orally	Overall response rate, CRP, ESR, DMS, and GS	6 M

Sun (2011) [31]	26/25	7.8 (1.5–14)	24/27	Unclear	TGP 30–60 mg/kg/d, oral. MTX 10 mg/m²/w, oral.	MTX 10 mg/m²/w, oral	Overall response rate, CRP, ESR, DMS, TJC, SJC, and AE	26 W

Zhao and Li (2011) [32]	17/15	8.1 ± 2.5	18/14	Poly 15, Pauci 10, and other 7	TGP 0.3 g, twice a day orally, MTX 10 mg/m², once a week orally.	MTX 10 mg/m² once a week orally	Overall response rate, CRP, and ESR	6 M, 12 M

Fang and Li (2012) [33]	23/22	8.1 ± 2.5	26/19	Systemic 45	TGP 0.3 g, twice a day orally, MTX 10 mg/m², once a week orally.	MTX 10 mg/m² once a week orally	Overall response rate, CRP, and ESR	6 M, 12 M

Wang (2012) [34]	31/30	10.6 ± 2.9	38/23	Pauci 46, poly 13, and systemic 2	TGP 0.6 g, 3 times a day orally, MTX 0.25–0.8 mg/kg, once a week orally.	MTX 0.25–0.8 mg/kg, once a week orally	Overall response rate, CRP, ESR, DMS, autoantibody, ACR70, JADAS, and AE	8 W, 12 W

Pauci: pauciarticular; poly: polyarticular; Lef: Leflunomide; Mel: meloxicam; DMS: duration of morning stiffness; TGP: total glucosides of peony; MTX: Methotrexate; TJC: tender joint count; SJC: swollen joint count; GS: grip strength; AE: adverse effect; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; JADAS: Juvenile Arthritis Disease Activity Score.