Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice

Figure 5

Effects of piperine on NF-κB pathway activation. (a) The expression of NF-κB p65 and I-κBα is shown. (b) The ratio of NF-κB p65 or I-κBα and β-actin. CG: control group, the mice without any treatment. S. aureus: the mouse model of S. aureus endometritis without any drug treatment. 25, 50, and 100: piperine treatment groups: the S. aureus endometritis mice were given piperine at 25 mg/kg, 50 mg/kg, and 100 mg/kg. DEX: the S. aureus endometritis mice were treated with dexamethasone at 5 mg/kg. β-actin was used as a control. Values are presented as the means ± SD. significantly compared with the CG; significantly compared with the S. aureus.

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