Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice

Figure 6

Effect of piperine on MAPK pathways activation. (a) The expression of p38, ERK, and JNK is shown. (b) The ratios of p38 or ERK or JNK with β-actin are shown. CG: control group, the mice without any treatment. S. aureus: the mouse model of S. aureus endometritis without any drug treatment. 25, 50, and 100: piperine treatment groups: the S. aureus endometritis mice were given piperine at 25 mg/kg, 50 mg/kg, and 100 mg/kg. DEX: the S. aureus endometritis mice were treated with dexamethasone at 5 mg/kg. β-actin was used as a control. represents statistical significance compared with the CG and represents statistical significance compared with the S. aureus group.

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