Ligustrazine for the Treatment of Unstable Angina: A Meta-Analysis of 16 Randomized Controlled Trials

Table 1

Characteristics of included studies.

Studies	Sample (t/c)	Diagnosis standard	Age	Intervention group	Control group	Course (day)	Outcome measures
Guo 2007 [25]	20/16	ISFC/WHO	59 ± 6.7	Ligustrazine injection, nitrates, aspirin, ACE inhibitor	Nitrates, aspirin, ACE inhibitor	14	IAS, NIWAS, IECG, NIWECG
Liao and Luo 2006 [26]	34/34	ISFC/WHO	46–71	Ligustrazine injection, nitrates, aspirin	Nitrates and aspirin	15	IAS and NIWAS
Da 2008 [27]	38/36	CSC	41–83	Ligustrazine injection, nitrates, aspirin, Low Molecular Weight Heparin (LMWH), beta blockers	Nitroglycerin, aspirin, LMWH, beta blockers	14	IAS, NIWAS, IECG, NIWECG
Rong et al. 2001 [28]	32/32	Other	64.3 ± 7.2	Ligustrazine injection, nitrates, aspirin	Nitrates and aspirin	10	IAS and NIWAS
Peng 2014 [29]	43/42	CSC	61.2 ± 5.94	Ligustrazine injection, nitrates, antiplatelet drugs	Nitrates and antiplatelet drugs	14	IAS, NIWAS, IECG, NIWECG, AOT, SF, RNU, FIB
Wang and Hua 2004 [30]	30/28	ISFC/WHO	Unclear	Ligustrazine injection, beta blockers, aspirin, calcium channel blockers (CCB), LMWH, ACE inhibitor	Beta blockers, aspirin, CCB, LMWH, ACE inhibitor	28	IAS and NIWAS
Wei et al. 2012 [31]	60/60	CSC	48–79	Ligustrazine injection, antiplatelet drugs, nitrates, beta blockers	Antiplatelet drugs, nitrates, beta blockers	14	IAS, NIWAS, AOT, SF, FIB
Wang 2006 [32]	65/65	CSC	67.5 ± 9	Ligustrazine injection, beta blockers, nitrates, aspirin, CCB, ACE inhibitor	Beta blockers, nitrates, aspirin, CCB, ACE inhibitor	14	IAS and NIWAS
Zhou 2008 [33]	78/50	ISFC/WHO	39–89	Ligustrazine injection, nitroglycerin, aspirin, CCB, beta blockers	Nitroglycerin, aspirin, CCB, beta blockers	14	IAS and NIWAS
Li 2010 [34]	38/30	Other	42–76	Ligustrazine injection, nitroglycerin, aspirin, LMWH, beta blockers	Nitroglycerin, aspirin, LMWH, beta blockers	14	IAS and NIWAS
Sun 2007 [35]	48/48	Other	48–80	Ligustrazine injection, nitrates, aspirin, beta blockers, statins, ACE inhibitor	Nitrates, aspirin, beta blockers, statins, ACE inhibitor	21	IAS, NIWAS, IECG, NIWECG, FIB
Wang 2008 [36]	42/42	ISFC/WHO	48–78	Ligustrazine injection, nitrates, aspirin, beta blockers, CCB, statins, ACE inhibitor	Nitrates, aspirin, beta blockers, CCB, statins, ACE inhibitor	14	IAS, NIWAS, IECG, NIWECG
Fan 2014 [37]	63/63	Other	73.5 ± 12.6	Ligustrazine injection, nitrates, aspirin, statins	Nitrates, aspirin, statins, beta blockers	14	IAS, NIWAS, IECG, NIWECG, AOT, SF, RNU
Fu and Lin 2009 [38]	40/41	Other	Unclear	Ligustrazine injection, nitrates, aspirin, statins, LMWH, beta blockers	Nitrates, aspirin, statins, LMWH, beta blockers	14	IAS and NIWAS
Meng et al. 2005 [39]	38/38	ISFC/WHO	68.8 ± 7.8	Ligustrazine injection, nitrates, beta blockers, ACE inhibitor, CCB, LMWH	Nitrates, beta blockers, ACE inhibitor, CCB, LMWH	10	IAS, NIWAS, IECG, NIWECG, FIB, CEs
Wang et al. 2005 [40]	32/30	ISFC/WHO	50–66	Ligustrazine injection, nitrates, aspirin, LMWH, beta blockers	Nitrates, aspirin, LMWH, beta blockers	14	IAS, NIWAS, IECG, NIWECG