Research Article

An Extract of Chinpi, the Dried Peel of the Citrus Fruit Unshiu, Enhances Axonal Remyelination via Promoting the Proliferation of Oligodendrocyte Progenitor Cells

Figure 1

Immunohistochemistry of coronal section of the cerebrum using anti-MBP antibody. Twenty-eight-month-old mice were treated with or without Chinpi in drinking water for 2 months. An overview of the gray and white matter at 30 months old is shown. Myelin stained with anti-MBP antibody (brown signals) reveals the vertical, myelinated nerve fibers running from the corpus callosum (CC) to the pia matter. The number of myelinated nerve fibers was increased after two months of Chinpi, and age-induced demyelination was reduced compared with controls. Scale bar = 28 μm.