Cortex phellodendri Extract Relaxes Airway Smooth Muscle

Figure 5

NBAECP inhibits bronchial smooth muscle contraction. (a) The intrapulmonary airway in a lung slice from a control mouse (left) following addition of ACH (10 μM for 10 min): the cross-section area of the airway lumen decreased (middle); then upon application of NBAECP (3.16 mg/mL for 15 min), the cross-section area of the airway lumen increased (right). (b) Similar measurements in an asthmatic lung slice. (c) Summary data from 8 slices/8 control mice and 5 slices/5 asthmatic mice. , . These experiments demonstrated that NBAECP could inhibit ACH-induced contraction in bronchial smooth muscle.

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