Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 8970585, 11 pages
http://dx.doi.org/10.1155/2016/8970585
Research Article

Effects of Hot Water Extracts from Polygonum multiflorum on Ovariectomy Induced Osteopenia in Mice

1Department of Pharmacy, Sunchon National University, Suncheon, Republic of Korea
2Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, No. 02-02 Helios, Singapore 138667
3Suncheon Research Center for Natural Medicines, Suncheon, Republic of Korea

Received 21 April 2016; Revised 9 August 2016; Accepted 14 August 2016

Academic Editor: Jairo Kennup Bastos

Copyright © 2016 Yun-Ho Hwang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S.-H. Tseng, C.-H. Sung, L.-G. Chen et al., “Comparison of chemical compositions and osteoprotective effects of different sections of velvet antler,” Journal of Ethnopharmacology, vol. 151, no. 1, pp. 352–360, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. Y.-H. Hwang, K.-J. Kim, J.-J. Kim et al., “Antiosteoporosis activity of new oriental medicine preparation (Kyungokgo mixed with water extract of Hovenia dulcis) on the ovariectomized mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 373145, 17 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. L. G. Raisz, “Pathogenesis of osteoporosis: concepts, conflicts, and prospects,” The Journal of Clinical Investigation, vol. 115, no. 12, pp. 3318–3325, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. E. Hernlund, A. Svedbom, M. Ivergård et al., “Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA),” Archives of Osteoporosis, vol. 8, article 136, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Masi, “Epidemiology of osteoporosis,” Clinical Cases in Mineral and Bone Metabolism, vol. 5, no. 1, pp. 11–13, 2008. View at Google Scholar
  6. L . Ginaldi, M. C. Di Benedetto, and M. De Martinis, “Osteoporosis, inflammation and ageing,” Immunity & Ageing, vol. 2, article 14, 2005. View at Publisher · View at Google Scholar
  7. K. J. Armour, K. E. Armour, R. J. van't Hof et al., “Activation of the inducible nitric oxide synthase pathway contributes to inflammation-induced osteoporosis by suppressing bone formation and causing osteoblast apoptosis,” Arthritis & Rheumatism, vol. 44, no. 12, pp. 2790–2796, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Kim, H. Ha, K.-S. Shim, W.-K. Cho, and J. Y. Ma, “The anti-osteoporotic effect of Yijung-tang in an ovariectomized rat model mediated by inhibition of osteoclast differentiation,” Journal of Ethnopharmacology, vol. 146, no. 1, pp. 83–89, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. P. D. Delmas, “Treatment of postmenopausal osteoporosis,” The Lancet, vol. 359, no. 9322, pp. 2018–2026, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Dutertre and C. L. Smith, “Molecular mechanisms of selective estrogen receptor modulator (SERM) action,” Journal of Pharmacology and Experimental Therapeutics, vol. 295, no. 2, pp. 431–437, 2000. View at Google Scholar · View at Scopus
  11. B.-S. Ahn, M. Yang, H. Jang et al., “Evaluation of the antiosteoporotic potential of Cimicifuga heracleifolia in female mice,” Phytotherapy Research, vol. 26, no. 5, pp. 663–668, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. H. D. Nelson, L. L. Humphrey, P. Nygren, S. M. Teutsch, and J. D. Allan, “Postmenopausal hormone replacement therapy: scientific review,” The Journal of the American Medical Association, vol. 288, no. 7, pp. 872–881, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Z. Zhang, S. X. Wang, Y. Zhang, J. P. Chen, and X. M. Liang, “In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms,” Journal of Ethnopharmacology, vol. 98, no. 3, pp. 295–300, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. N. Sun, L. Cui, W. Li et al., “Promotion effect of constituents from the root of Polygonum multiflorum on hair growth,” Bioorganic and Medicinal Chemistry Letters, vol. 23, no. 17, pp. 4801–4805, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. X. Li, K. Matsumoto, Y. Murakami, Y. Tezuka, Y. Wu, and S. Kadota, “Neuroprotective effects of Polygonum multiflorum on nigrostriatal dopaminergic degeneration induced by paraquat and maneb in mice,” Pharmacology Biochemistry and Behavior, vol. 82, no. 2, pp. 345–352, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Lv, Y. Cheng, T. Zheng, X. Li, and R. Zhai, “Purification, antioxidant activity and antiglycation of polysaccharides from Polygonum multiflorum Thunb,” Carbohydrate Polymers, vol. 99, pp. 765–773, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. M. L. Steele, J. Truong, S. Govindaraghavan, L. Ooi, N. J. Sucher, and G. Münch, “Cytoprotective properties of traditional Chinese medicinal herbal extracts in hydrogen peroxide challenged human U373 astroglia cells,” Neurochemistry International, vol. 62, no. 5, pp. 522–529, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. H.-J. Park, N. Zhang, and D. K. Park, “Topical application of Polygonum multiflorum extract induces hair growth of resting hair follicles through upregulating Shh and β-catenin expression in C57BL/6 mice,” Journal of Ethnopharmacology, vol. 135, no. 2, pp. 369–375, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Li, F. Cai, Y. Yang et al., “Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-β1 pathway,” European Journal of Pharmacology, vol. 649, no. 1–3, pp. 382–389, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. N. Lai, Z. Zhang, B. Wang et al., “Regulatory effect of traditional Chinese medicinal formula Zuo-Gui-Wan on the Th17/Treg paradigm in mice with bone loss induced by estrogen deficiency,” Journal of Ethnopharmacology, vol. 166, pp. 228–239, 2015. View at Publisher · View at Google Scholar
  21. J.-K. Zhang, L. Yang, G.-L. Meng et al., “Protective effect of tetrahydroxystilbene glucoside against hydrogen peroxide-induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells,” European Journal of Pharmacology, vol. 689, no. 1–3, pp. 31–37, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. L.-C. Lin, S. M. Nalawade, V. Mulabagal, M.-S. Yeh, and H.-S. Tsay, “Micropropagation of Polygonum multiflorum Thunb and quantitative analysis of the anthraquinones emodin and physcion formed in in vitro propagated shoots and plants,” Biological and Pharmaceutical Bulletin, vol. 26, no. 10, pp. 1467–1471, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Srinivas, S. Babykutty, P. P. Sathiadevan, and P. Srinivas, “Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent,” Medicinal Research Reviews, vol. 27, no. 5, pp. 591–608, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. J.-K. Hwang, E.-M. Noh, S.-J. Moon et al., “Emodin suppresses inflammatory responses and joint destruction in collagen-induced arthritic mice,” Rheumatology, vol. 52, no. 9, Article ID ket178, pp. 1583–1591, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. J.-Y. Kim, Y.-H. Cheon, S. C. Kwak et al., “Emodin regulates bone remodeling by inhibiting osteoclastogenesis and stimulating osteoblast formation,” Journal of Bone and Mineral Research, vol. 29, no. 7, pp. 1541–1553, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. X. Wang, L. Zhao, T. Han, S. Chen, and J. Wang, “Protective effects of 2,3,5,4′-tetrahydroxystilbene-2-O-beta-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice,” European Journal of Pharmacology, vol. 578, no. 2-3, pp. 339–348, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Z. Zhang, J. F. Shen, J. Y. Xu, J. H. Xiao, and J. L. Wang, “Inhibitory effects of 2,3,5,4′-tetrahydroxystilbene-2-O-beta-D-glucoside on experimental inflammation and cyclooxygenase 2 activity,” Journal of Asian Natural Products Research, vol. 9, no. 3–5, pp. 355–363, 2007. View at Publisher · View at Google Scholar
  28. T. Wang, J. Gu, P.-F. Wu et al., “Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-κB pathways and inhibition of intracellular ROS/RNS generation,” Free Radical Biology and Medicine, vol. 47, no. 3, pp. 229–240, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. A. C. Gören, S. Çikrikçi, M. Çergel, and G. Bilsel, “Rapid quantitation of curcumin in turmeric via NMR and LC-tandem mass spectrometry,” Food Chemistry, vol. 113, no. 4, pp. 1239–1242, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Wang, L. Song, S. Feng et al., “Characterization of proanthocyanidins in stems of Polygonum multiflorum thunb as strong starch hydrolase inhibitors,” Molecules, vol. 18, no. 2, pp. 2255–2265, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. X.-G. He, “On-line identification of phytochemical constituents in botanical extracts by combined high-performance liquid chromatographic-diode array detection-mass spectrometric techniques,” Journal of Chromatography A, vol. 880, no. 1-2, pp. 203–232, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Yi, K. S. Y. Leung, G.-H. Lu, H. Zhang, and K. Chan, “Identification and determination of the major constituents in traditional Chinese medicinal plant polygonum multiflorum Thunb by HPLC coupled with PAD and ESI/MS,” Phytochemical Analysis, vol. 18, no. 3, pp. 181–187, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Canonico, G. Plu-Bureau, G. D. O. Lowe, and P.-Y. Scarabin, “Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: systematic review and meta-analysis,” British Medical Journal, vol. 336, no. 7655, pp. 1227–1231, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. M. J. Sung, M. Davaatseren, H. J. Hur et al., “Antiosteoporotic activity of Saururus chinensis extract in ovariectomized rats,” Phytotherapy Research, vol. 26, no. 8, pp. 1182–1188, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. A. M. Tyagi, K. Srivastava, K. Sharan, D. Yadav, R. Maurya, and D. Singh, “Daidzein prevents the increase in CD4+CD28null T cells and B lymphopoesis in ovariectomized mice: a key mechanism for anti-osteoclastogenic effect,” PLoS ONE, vol. 6, no. 6, Article ID e21216, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. J. A. Park, S. K. Ha, T. H. Kang et al., “Protective effect of apigenin on ovariectomy-induced bone loss in rats,” Life Sciences, vol. 82, no. 25-26, pp. 1217–1223, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. C. Ohlsson, B.-Å. Bengtsson, O. G. P. Isaksson, T. T. Andreassen, and M. C. Slootweg, “Growth hormone and bone,” Endocrine Reviews, vol. 19, no. 1, pp. 55–79, 1998. View at Google Scholar · View at Scopus
  38. J. A. Kanis, “Diagnosis of osteoporosis and assessment of fracture risk,” The Lancet, vol. 359, no. 9321, pp. 1929–1936, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. X. Zhao, Z.-X. Wu, Y. Zhang et al., “Anti-osteoporosis activity of Cibotium barometz extract on ovariectomy-induced bone loss in rats,” Journal of Ethnopharmacology, vol. 137, no. 3, pp. 1083–1088, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. M. H. Siddiqi, M. Z. Siddiqi, S. Kang et al., “Inhibition of osteoclast differentiation by ginsenoside Rg3 in RAW264.7 cells via RANKL, JNK and p38 MAPK pathways through a modulation of cathepsin K: an in silico and in vitro study,” Phytotherapy Research, vol. 29, no. 9, pp. 1286–1294, 2015. View at Publisher · View at Google Scholar · View at Scopus
  41. X. C. Xu, H. Chen, X. Zhang et al., “Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy,” Journal of Translational Medicine, vol. 12, article 284, 2014. View at Publisher · View at Google Scholar
  42. S. R. Fahmy, A. M. Soliman, A. A. Sayed, and M. Marzouk, “Possible antiosteoporotic mechanism of Cicer arietinum extract in ovariectomized rats,” International Journal of Clinical and Experimental Pathology, vol. 8, no. 4, pp. 3477–3490, 2015. View at Google Scholar · View at Scopus
  43. Y.-E. Lee, H.-C. Liu, Y.-L. Lin, S.-H. Liu, R.-S. Yang, and R.-M. Chen, “Drynaria fortunei J. Sm. improves the bone mass of ovariectomized rats through osteocalcin-involved endochondral ossification,” Journal of Ethnopharmacology, vol. 158, pp. 94–101, 2014. View at Publisher · View at Google Scholar · View at Scopus
  44. B. Gjoksi, C. Ghayor, B. Siegenthaler, N. Ruangsawasdi, M. Zenobi-Wong, and F. E. Weber, “The epigenetically active small chemical N-methyl pyrrolidone (NMP) prevents estrogen depletion induced osteoporosis,” Bone, vol. 78, pp. 114–121, 2015. View at Publisher · View at Google Scholar · View at Scopus