Systems Pharmacology Based Study of the Molecular Mechanism of SiNiSan Formula for Application in Nervous and Mental Diseases

Table 1

High correlation diseases with potential targets of SNS formula.

Disease name	Related targets (gene) symbol	MeSH class	Degree
Autistic disorder	APC, PRF1, HTR1D, CHRNA7, OXTR, DRD3, DHCR7, XDH, AR, CHRNA4, HTR3A, HTR2A, HTR2C, IGFBP3, KCNMA1, MAOB	Mental disorder	18
Schizophrenia	CHRNA7, CYP2D6, NOS1, BCHE, HRH1, HTR2A, HTR3A, NR3C1, OXTR, DRD3, GSK3B, MC4R, HTR2C, KCNMA1, MAOB, GRIN2B, CYP1A2	Mental disorder	18
Epilepsy	UGT2B7, GRIN2B, SV2A, CYP1A1, ABCG2, CHRM2, CYP2C9, CYP2A6, HRH1, OPRM1, ADRA2A, CHRNA4, BDKRB1, CHRNA7, CYP2D6, BCHE	Nervous system diseases	17
Peripheral nervous system diseases	ALOX12, PARP2, CYP1A2, SLC10A2, TLR4, CCL5, UGT2B7, TRPC4, ESR1, SRD5A2, SRD5A1, ELOVL6, CES1, ABCC1, CYP24A1, POLB	Nervous system diseases	17
Obesity	MLNR, MCHR1, CES1, STS, PTPN1, BCHE, HTR2C, ACACB, MC4R, MMP9, ESRRA, CCK, HTR2A, ESR1, KCNMA1	Nutritional and metabolic diseases	16
Pain	HRH1, BDKRB1, OPRK1, CHRNA4, CHRNA7, GRIN2B, F2R, OPRM1, CHRM4, P2RX3, CNR2, CHRM2	Nervous system diseases	13
Seizures	OPRM1, CHRNA7, CHRNA4, DRD3, CCK, CYP1A1, HCN1, NOS1, SIGMAR1, BCHE, OPRK1	Nervous system diseases	12
Atherosclerosis	TLR4, HRH1, F3, ESR1, ALOX5, NR1H2, CNR2, LTA4H, CES1, PLA2G2A, MMP9	Vascular diseases	12
Hypertension	HTR2B, NR3C1, HSD11B2, CYP3A4, CYP1A1, ADCY5, ABCC1, ADRA2A, AR, ATP1A1, EDNRA	Vascular diseases	12
Diabetes mellitus, type 2	PYGM, GAA, CYP2C9, TNFRSF1A, EDNRB, CYP1A2, PTPN1, EDNRA, KCNQ1, ADCY5	Nutritional and metabolic diseases	12
Hyperalgesia	ALOX12, P2RX3, OPRM1, CNR2, ALOX5, NOS1, DRD3, HTR2A, BDKRB1, GRIN2B	Nervous system diseases	11
Alzheimer disease	HTR2A, ESR1, GSK3B, BCHE, CYP2D6, CALM1, MAPT, CHRNA7, APP	Nervous system diseases	10
Heart failure	NR3C2, XDH, NOX4, GSK3B, ATP2A1, ADRA2A, ATP1A1, TNFRSF1A, HTR2B	Heart diseases	10
Myocardial infarction	ABCG2, GSK3B, CYP1A2, LTA4H, CYP2C9, NR3C2, HSD11B2, ESR1, MMP9	Heart diseases	10