| | Study | Number of participants (TG/CG)/number of drop-outs (TG/CG) | Duration (week) | Treatment group intervention | Control group intervention | CHM formula and ingredients | Assessment of outcomes |
| |
Liang et al. 2015 [17] | 98 (48 + 50)/0 | 24 | CHM + chemotherapy | Chemotherapy: TAC: TAX/ADM/CTX, or TA: TAX/ADM, or GT: GCB/TAX, or EC: EPI/CTX | Huaier Granule (did not mention specific ingredient) | Survival rate, CD4,
CD4/CD8, IL-2, chemotoxicity |
| |
Du et al. 2015 [18] | 60 (30 + 30)/0 | 16 | CHM + FAC | FAC: 5-FU/ADM/CTX | Modified Xiaoyao powder (Radix Bupleuri, Angelica sinensis, Radix Paeoniae Alba, Roasted Rhizoma Atractylodis Macrocephalae, Poria cocos, Ginger, Mint, Radix Liquiritiae) | KPS, chemotoxicity, survival rate, recurrence rate, clinical symptoms |
| | Li 2015 [24] | 85 (44 + 41)/0 | 9 | CHM + CEF | CEF: CTX/EPI/5-FU | Fuzheng Xiaoliu compound (Radix Astragalus, Codonopsis pilosula, Fructus Lycii, Scutellaria barbata, Agrimonia pilosa, Pleione bulbocodioides, Curcuma Zedoary, Rhizoma Sparganii, Coix Seed, Rhizoma, Pericarpium Citri Reticulatae, Licorice Roots Northwest Origin) | Tumor response, chemotoxicity, serum tumor marker |
| | Li and Han 2015 [52] | 60 (30 + 30)/0 | 12 | CHM + TAC | TAC: TAX/ADM/CTX | Yiqihuoxue compound (Radix Astragalus, Coix Seed, Radix Pseudostellariae, Peach Kernel, Flos Carthami, Rhizoma Atractylodis Macrocephalae, Angelica sinensis, Red Peony Root, Cowherb Seed, Pericarpium Citri Reticulatae, Radix Liquiritiae) | RECIST, KPS |
| |
Chen et al. 2015 [25] | 60 (28 + 29)/3 | 6 | CHM + GP | GP: GCB/PDD | Sugan Jianpi Sanjie compound (Radix Astragalus, Radix Bupleuri, Pericarpium Citri Reticulatae, Radix Curcumae, Pleione bulbocodioides, Rhizoma Atractylodis Macrocephalae, Coix Seed, Oldenlandia diffusa, Scutellaria barbata, Semen Raphani, Polygonatum Kingianum, Radix Liquiritiae) | Chemotoxicity, KPS, CD3, CD4,
CD4/CD8, serum tumor marker |
| | Wang 2015 [26] | 60 (30 + 30)/0 | 4 | CHM + FD | FD: 5-FU/DDP | Xiaozheng compound (Radix Astragalus, Codonopsis pilosula, Oldenlandia diffusa, Scutellaria barbata, Pericarpium Citri Reticulatae Viride, Akebia Fruit, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Tangerine Seed) | Tumor response, chemotoxicity, survival rate |
| |
Fang and Jia 2015 [27] | 30 (16 + 14)/0 | 12 | CHM + CE | CE: CTX + EPI | Chinese herbal compound (Radix Astragalus, Codonopsis pilosula, Roasted Rhizoma atractylodis macrocephalae, Poria cocos, Peach Kernel, Flos Carthami, Red Peony Root, Radix Paeoniae Alba, Radix Isatidis, Nidus Vespae, Dried Radix Rehmanniae, Angelica sinensis, Caulis Spatholobi) | Tumor response, chemotoxicity, KPS |
| |
Bai and Wu 2014 [28] | 64 (32 + 32)/0 | 12 | CHM + TEC | TEC: TAX/EPI/CTX | Jinlong capsule (did not mention specific ingredient) | Tumor response, chemotoxicity, KPS |
| | Guo 2014 [29] | 76 (38 + 38)/0 | 8 | CHM + CAF | CAF: CTX/ADM/5-FU | Fuzheng Quji decoction (Radix Astragalus, Caulis Spatholobi, Rhizoma Sparganii, Concha Ostreae, Curcuma Zedoary, Turtle Shell, Sargassum, Roasted Rhizoma Atractylodis Macrocephalae, Polygonatum Kingianum, Codonopsis pilosula, Endothelium Corneum Gigeriae Galli, Amomum villosum, Dried Lacquer, Angelica sinensis, Fructus Lycii) | Tumor response, chemotoxicity, |
| | Xie 2014 [30] | 90 (45 + 45)/0 | 18 | CHM + CAF | CAF: CTX/ADM/5-FU | Shenqifuzheng injection (Radix Astragalus, Codonopsis pilosula) | Tumor response, chemotoxicity, peripheral blood lymphocytes |
| |
Yang et al. 2014 [31] | 86 (43 + 43)/0 | 2 | CHM + TA | TAX/ADM | The beginning of chemotherapy: Xiangsha Liujunzi decoction (Rhizoma Atractylodis Macrocephalae, Codonopsis pilosula, Rhizoma, Pericarpium Citri Reticulatae, Poria cocos, Chinese Yam, Semen Raphani, Coke Hawthorn Coke Malt, Coke Medicated Leaven, Caulis Bambusae in Taeniam, Purple Perilla, Amomum villosum, Costustoot); the middle-late stages of chemotherapy: Liuweidihuang decoction (Poria cocos, Chinese Yam, Rhizoma Atractylodis Macrocephalae, Cornus officinalis, Shorthorned Epimedium, Semen Cuscutae, Mulberry, Radix Rehmanniae Preparata, Rhizoma Alismatis, Caulis Spatholobi, Radix Astragalus, Polygonatum Kingianum) | Tumor response, chemotoxicity |
| |
Cheng et al. 2013 [32] | 40 (20 + 20)/0 | 3 | CHM + CAP | CAP: CTX/ADM/PDD | Modified Lizhong decoction (Red Ginseng, Dried Ginger, Rhizoma Atractylodis Macrocephalae, Radix Liquiritiae, Cornus officinalis, Fructus Schizandrae, Poria cocos, Radix Paeoniae Alba) | Chemotoxicity, KPS |
| | Wang 2013 [33] | 76 (38 + 38)/0 | 2 | CHM + CAF | CAF: CTX/ADM/5-FU | Shenqifuzheng injection (Radix Astragalus, Codonopsis pilosula) | Tumor response, chemotoxicity, KPS |
| | Xiong 2012 [34] | 48 (24 + 24)/0 | 6 | CHM + CN | CN: CAP + NDP | Fuzheng Xiaoji compound (Radix Astragalus, Polygonatum Kingianum, Codonopsis pilosula, Rhizoma Atractylodis Macrocephalae, Angelica sinensis, Fructus Lycii, Tortoiseshell, Endothelium Corneum Gigeriae Galli, Caulis Spatholobi, Sargassum, Concha Ostreae) | RECIST, KPS, serum tumor marker |
| |
Zhang and Dang 2012 [35] | 60 (30 + 30)/0 | 4 | CHM + NP | NP: NDP/PDD | Fuzheng Guben compound (Codonopsis pilosula, Curcuma Zedoary, Coix Seed, Coke Hawthorn, Coke Medicated Leaven, Endothelium Corneum Gigeriae Galli, Roasted Rhizoma Atractylodis Macrocephalae, Radix Astragalus, Rhizoma, Pericarpium Citri Reticulatae, Radix Paeoniae Alba, Radix Liquiritiae) | RECIST, KPS, chemotoxicity |
| | Pan 2011 [36] | 160 (80 + 80)/0 | 4 | CHM + CAF | CAF: CTX/ADM/5-FU | Cinobufagin | KPS, chemotoxicity |
| |
Liu et al. 2011 [53] | 66 (31 + 35)/0 | 24 | CHM + CAF | CAF: CTX/ADM/5-FU | Tianzhicao capsule (did not mention specific ingredient) | KPS, chemotoxicity |
| | Liu et al. 2011 [54] | 50 (25 + 25)/0 | 6 | CHM + TE | TE: TAX/EPI | Renshen Yangrong decoction (Codonopsis pilosula, Radix Astragalus, Radix Rehmanniae Preparata, Radix Paeoniae Alba, Poria cocos, Pericarpium Citri Reticulatae, Rhizoma Atractylodis Macrocephalae, Angelica sinensis Fructus Schizandrae, Polygala tenuifolia, Radix Liquiritiae, Cinnamon, Ginger, Jujube) | KPS, CD3, CD4,
CD4/CD8, CD8, clinical symptoms |
| | Yang 2011 [37] | 64 (32 + 32)/0 | 12 | CHM + TA | TA: TAX/ADM | Shenxiao Gualousan (Radix Bupleuri, Corydalis Tuber, Snakegourd Fruit, Fritillary Bulb, Angelica sinensis, Scrophulariae, Phillyrin, Sargassum, Laminaria, Olibanum, Commiphora myrrha) | Tumor response, chemotoxicity |
| | Cheng 2011 [38] | 50 (26 + 24)/0 | 8 | CHM + TP | TP: TAX/ PDD | Fuzheng Kanai compound (Radix Astragalus, Angelica sinensis, Radix Pseudostellariae, Roasted Rhizoma Atractylodis Macrocephalae, Poria cocos, Coix Seed, Shorthorned Epimedium, Cornus officinalis, Radix Bupleuri, Rhizoma Cyperi, Oldenlandia diffusa, Curcuma Zedoary, Radix Liquiritiae) | Tumor response, KPS, CD3, CD4,
CD8, clinical symptoms |
| |
Zhang et al. 2011 [39] | 45 (23 + 22)/0 | 6 | CHM + CTF | CTF: CTX/TAX/5-FU | Xiaoyan decoction (Codonopsis pilosula, Radix Astragalus, Ligustrum lucidum Ait., Radix Curcuma, Radix Curcumae, Sophora flavescens, Oldenlandia diffusa) | KPS, CD3, CD4,
CD8, CD4/CD8, serum tumor marker, chemotoxicity |
| |
Feng et al. 2010 [40] | 60 (32 + 28)/0 | 3 | CHM + NFL | NFL: MTX/CF/5-FU | Wu Mei Wan (Concha Ostreae, Fructus Mume, processed Radix Aconiti Lateralis, Dried Ginger, Cassia Twig, Capsicum annuum, Radix Liquiritiae, Amomum villosum) | Tumor response, KPS |
| | Zhang 2009 [41] | 50 (26 + 24)/0 | 4 | CHM + NP | NP: NDP/PDD | Chinese herbal compound (Radix Astragalus, Oldenlandia diffusa, Nidus Vespae, Angelica sinensis, Radix Pseudostellariae, Roasted Rhizoma Atractylodis Macrocephalae, Poria cocos, Coix Seed, Cornus officinalis, Achyranthes bidentata, Radix Bupleuri, Radix Paeoniae Alba, Curcuma, Pericarpium Citri Reticulatae, Rhizoma, Fructus Aurantii) | Tumor response, clinical symptoms, KPS, chemotoxicity |
| |
Yang et al. 2008 [42] | 59 (28 + 27)/4 | 12 | CHM + NP | NP: NDP/PDD | Guben Yiliu II (Codonopsis pilosula, Poria cocos, Rhizoma Atractylodis Macrocephalae, Radix Astragalus, Ligustrum lucidum Ait., Fructus Lycii, Shorthorned Epimedium, Rhizoma Chuanxiong, Caulis Spatholobi, Curcuma Zedoary, Fritillary Bulb, Sophora flavescens) | Tumor response, KPS, serum tumor marker, clinical symptoms, chemotoxicity |
| |
Hu et al. 2008 [43] | 52 (28 + 24)/0 | 20 d | CHM + CAF | CAF: CTX/ADM/5-FU | Yiqihuoxue decoction (Codonopsis pilosula, Radix Astragalus, Angelica sinensis, Colla Corii Asini, Pseudoginseng, Peach Kernel, Flos Carthami, Rhizoma Atractylodis Macrocephalae, Coix Seed, Fructus Lycii, Eucommia ulmoides, Fritillary Bulb, Selfheal) | Tumor response, chemotoxicity |
| |
Chen et al. 2008 [16] | 60 (30 + 30)/0 | 24 | CHM + CEF | CEF: CTX/EPI/5-FU | Dangguibuxue decoction (Radix Astragalus, Angelica sinensis) | Quality of life, chemotoxicity, CD3, CD4,
CD8, CD4/CD8 |
| |
Tang et al. 2007 [44] | 60 (30 + 30)/0 | 12 | CHM + CEF | CEF: CTX/EPI/5-FU | Yiqijiedu decoction (Radix Astragalus, Angelica sinensis, Caulis Spatholobi, Ligustrum lucidum Ait., Selfheal, Radix Bupleuri, Coke Hawthorn, Coke Malt, Coke Medicated Leaven) | Clinical symptoms, CD4,
CD8, CD4/CD8, KPS |
| |
Huang et al. 2007 [45] | 60 (30 + 30)/0 | 6 | CHM + CTF | CTF: CTX/TAX/5-FU | Jianpi Xiaoji decoction (Radix Pseudostellariae, Radix Astragalus, Coix Seed, Rhizoma Atractylodis Macrocephalae, Poria cocos, Oldenlandia diffusa, Fructus Aurantii, Pericarpium Citri Reticulatae, Radix Liquiritiae) | Tumor response, KPS, chemotoxicity, CD3, CD4,
CD8, CD4/CD8 |
| |
Yang et al. 2007 [46] | 38 (20 + 18)/0 | 9 | CHM + CEF | CEF: CTX/EPI/5-FU | Taohongsiwu decoction (Radix Paeoniae Alba, Rhizoma Chuanxiong, Angelica sinensis, Flos Carthami, Radix Rehmanniae Preparata, Peach Kernel) | Tumor response, clinical symptoms, chemotoxicity |
| |
Dai et al. 2004 [47] | 46 (25 + 21)/0 | 6 | CHM + NP | NP: NDP/PDD | Tiaoganyangxue compound (Radix Bupleuri, Dried Radix Rehmanniae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, Angelica sinensis, Radix Paeoniae Alba, Poria cocos, Rhizoma Atractylodis Macrocephalae, Radix Astragalus, Radix Pseudostellariae, Snakegourd Fruit, Fritillary Bulb, Concha Ostreae, Uniflower Swisscentaury Root, Cowherb Seed, Stir-baked Squama Manitis, Dandelion) | Tumor response, chemotoxicity, KPS |
| |
Li et al. 2004 [48] | 75 (40 + 35)/0 | 12 | CHM + NE | NE: NDP/ EPI | Shenqifuzheng injection (Codonopsis pilosula, Radix Astragalus) | Tumor response, chemotoxicity |
| |
Yang and Sun 2004 [49] | 51 (27 + 24)/0 | 9 | CHM + CMF | CMF: CTX/MTX/5-FU | Modified Liujunzi decoction (Codonopsis pilosula, Poria cocos, Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma, Radix Liquiritiae, Radix Astragalus, Angelica sinensis, Radix Rehmanniae Preparata, Ligustrum lucidum Ait., Morinda officinalis, Fructus Psoraleae) | Cellular immune function, tumor response, chemotoxicity |
| |
Huang et al. 2003 [50] | 66 (37 + 29)/0 | 6 | CHM + CMF | CMF: CTX/MTX/5-FU | Modified Bazhen decoction (Radix Rehmanniae Preparata, Angelica sinensis, Rhizoma Atractylodis Macrocephalae, Poria cocos, Rhizoma Chuanxiong, Radix Paeoniae Alba, Codonopsis pilosula, Radix Astragalus, Radix Liquiritiae, Ligustrum lucidum Ait., Pericarpium Citri Reticulatae) | Tumor response, KPS, chemotoxicity, clinical symptoms |
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