Review Article

Immune Signatures in Patients with Psoriasis Vulgaris of Blood-Heat Syndrome: A Systematic Review and Meta-Analysis

Table 2

Summary of immunological markers of blood-heat syndrome.

SourceMarkers used ELISA measurement methods, mean (SD)
IFN-γ (pg/mL)IL-4 (pg/mL)IL-17 (pg/mL)IL-23 (pg/mL)IL-6 (pg/mL)TNF-α (pg/mL)IL-10 (pg/mL)

Cao et al. [10]Control 47.44 (21.46);
psoriasis 91.20 (48.37)
Control 47.41 (14.26);
psoriasis 32.73 (7.90)
Control 49.15 (31.18);
psoriasis 60.30 (48.08)

Chen et al. [11]Control 46.00 (0.67);
psoriasis 86.48 (46.44)
Control 48.45 (13.63);
psoriasis 32.52 (8.13)

Chen and Yang [23]Control 20.70 (13.20);
psoriasis 81.40 (15.10)
Control 201.00 (78.00);
psoriasis 529.00 (202.00)

Fan et al. [12]  Control 2.85 (0.64);
psoriasis 7.32 (2.01)
Control 814.93 (372.51);
psoriasis 1491.80 (464.36)
Control 109.32 (7.22);
psoriasis 418.05 (108.83)
  

He et al. [13] Control 30.07 (3.36);
psoriasis 11.29 (3.70)
  Control 7.40 (1.56);
psoriasis 30.58 (7.14)
 

Hu and Yang [24]Control 8.72 (2.04);
psoriasis 24.10 (8.13)
Control 30.21 (3.40);
psoriasis 19.89 (1.19)
  Control 74.30 (24.14);
psoriasis 130.26 (21.99)
 

Li [14]Control 69.16 (29.99);
psoriasis 98.68 (49.65)
Control 86.65 (41.26);
psoriasis 131.24 (41.24)
Control 85.73 (27.96);
psoriasis 105.60 (35.27)

Li [15]    Control 6.43 (0.33);
psoriasis 15.29 (0.49)
Control 18.25 (1.44);
psoriasis 6.51 (0.97)

Lin et al. [16]Control 8.72 (2.06);
psoriasis 24.10 (7.84)
    Control 21.27 (4.80);
psoriasis 8.59 (4.97)

Liu [17]Control 10.86 (5.41);
psoriasis 14.19 (6.84)
Control 67.65 (17.01);
psoriasis 63.69 (20.23)
Control 46.89 (9.13);
psoriasis 55.43 (13.76)
Control 24.39 (7.57);
psoriasis 16.84 (6.74)

Liu et al. [18]Control 6.24 (1.66);
psoriasis 23.37 (2.40)
Control 6.95 (0.83);
psoriasis 23.12 (1.89)

Sun and Zho [19]Control 8.63 (0.88);
psoriasis 11.37 (2.80)
Control 21.65 (1.53);
psoriasis 39.44 (6.11)

Wu et al. [25]Control 46.69 (11.43);
psoriasis 114.60 (19.78)
Control 24.39 (2.27);
psoriasis 14.14 (1.62)

Zhang [20]Control 7.37 (0.85);
psoriasis 26.67 (17.78)

Zhang et al. [21]Control 8.59 (2.59);
psoriasis 11.50 (4.48)
Control 78.20 (43.00);
psoriasis 239.06 (159.11)
Control 6.5 (3.1);
psoriasis 12.8 (7.4)

Zhou [22]Control 71.43 (45.90);
psoriasis 244.41 (133.25)
Control 5.9 (3.4);
psoriasis 11.3 (7.8)

Zhou and Wang [26]Control 33.34 (4.50);
psoriasis 96.14 (12.29)
Control 25.91 (3.69);
psoriasis 12.88 (2.66)
   Control 8.09 (1.06);
psoriasis 32.64 (6.23)
Control 21.96 (3.16);
psoriasis 12.77 (2.70)

ELISA, enzyme-linked immunosorbent assay; SD, standard deviation; IFN, interferon; IL, interleukin; TNF, tumor necrosis factor.