Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2016 (2016), Article ID 9593716, 8 pages
http://dx.doi.org/10.1155/2016/9593716
Research Article

Jujuboside A Protects H9C2 Cells from Isoproterenol-Induced Injury via Activating PI3K/Akt/mTOR Signaling Pathway

1CAU-BUA TCVM Teaching and Researching Team, College of Veterinary Medicine, China Agricultural University (CAU), Beijing 100193, China
2Beijing Key Laboratory of Dairy Cow Nutrition, College of Animal Science and Technology, Beijing University of Agriculture (BUA), Beijing 102206, China
3Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China

Received 25 February 2016; Accepted 26 April 2016

Academic Editor: Ki-Wan Oh

Copyright © 2016 Dandan Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. O. Kiss, E. Zima, P. Soos, V. Kékesi, A. Juhász-Nagy, and B. Merkely, “Intracoronary endothelin-1 infusion combined with systemic isoproterenol treatment: antagonistic arrhythmogenic effects,” Life Sciences, vol. 75, no. 5, pp. 537–548, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. P. T. Devika and P. S. M. Prince, “Preventive effect of (−)epigallocatechin-gallate (EGCG) on lysosomal enzymes in heart and subcellular fractions in isoproterenol-induced myocardial infarcted Wistar rats,” Chemico-Biological Interactions, vol. 172, no. 3, pp. 245–252, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. M. F. N. Meeran, P. S. M. Prince, and R. H. Basha, “Preventive effects of N-acetyl cysteine on lipids, lipoproteins and myocardial infarct size in isoproterenol induced myocardial infarcted rats: an in vivo and in vitro study,” European Journal of Pharmacology, vol. 677, no. 1–3, pp. 116–122, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. V. Patel, A. Upaganlawar, R. Zalawadia, and R. Balaraman, “Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: a biochemical, electrocardiographic and histoarchitectural evaluation,” European Journal of Pharmacology, vol. 644, no. 1–3, pp. 160–168, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Madhesh and M. Vaiyapuri, “Luteolin a dietary flavonoid attenuates isoproterenol-induced myocardial oxidative stress in rat myocardium: an in vivo study,” Biomedicine and Preventive Nutrition, vol. 3, no. 2, pp. 159–164, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Meena, L. A. Rajan, and R. Anandan, “Protective effect of betaine on protein, glycoproteins and amino acids in isoprenaline-induced myocardial infarction in albino rats,” Biomedicine and Preventive Nutrition, vol. 4, no. 3, pp. 403–409, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. K. H. S. Farvin, R. Anandan, S. H. S. Kumar, K. S. Shiny, T. V. Sankar, and T. K. Thankappan, “Effect of squalene on tissue defense system in isoproterenol-induced myocardial infarction in rats,” Pharmacological Research, vol. 50, no. 3, pp. 231–236, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Z. Shao, B. Redfors, M. S. Täng et al., “Novel rat model reveals important roles of β-adrenoreceptors in stress-induced cardiomyopathy,” International Journal of Cardiology, vol. 168, no. 3, pp. 1943–1950, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. E. J. Jeong, H. K. Lee, K. Y. Lee et al., “The effects of lignan-riched extract of Shisandra chinensis on amyloid-β-induced cognitive impairment and neurotoxicity in the cortex and hippocampus of mouse,” Journal of Ethnopharmacology, vol. 146, no. 1, pp. 347–354, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Zhang, Y. Zhang, and J. Xie, “Simultaneous determination of jujuboside A, B and betulinic acid in semen Ziziphi spinosae by high performance liquid chromatography-evaporative light scattering detection,” Journal of Pharmaceutical and Biomedical Analysis, vol. 48, no. 5, pp. 1467–1470, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. Z. Liu, X. Zhao, B. Liu et al., “Jujuboside A, a neuroprotective agent from semen Ziziphi Spinosae ameliorates behavioral disorders of the dementia mouse model induced by Aβ1−42,” European Journal of Pharmacology, vol. 738, pp. 206–213, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. Z.-L. You, Q. Xia, F.-R. Liang et al., “Effects on the expression of GABAA receptor subunits by jujuboside A treatment in rat hippocampal neurons,” Journal of Ethnopharmacology, vol. 128, no. 2, pp. 419–423, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. J.-X. Cao, Q.-Y. Zhang, S.-Y. Cui et al., “Hypnotic effect of jujubosides from Semen Ziziphi Spinosae,” Journal of Ethnopharmacology, vol. 130, no. 1, pp. 163–166, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. S. Huang, Y. Y. Pan, and Y. H. Jia, “A study of anti-apoptosis effect and mechanism of Jujuboside A in hydrogen peroxide damaged myocardial cell,” Liaoning Journal of Traditional Chinese Medicine, vol. 38, no. 3, pp. 454–455, 2011. View at Google Scholar
  15. X.-X. Wang, G.-I. Ma, J.-B. Xie, and G.-C. Pang, “Influence of JuA in evoking communication changes between the small intestines and brain tissues of rats and the GABAA and GABAB receptor transcription levels of hippocampal neurons,” Journal of Ethnopharmacology, vol. 159, pp. 215–223, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. C. S. Oehmen and S. S. Demir, “Three distinct types of pacemaker cells in the sinoatrial node: computer simulations,” in Proceedings of the 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society,, vol. 1, no. 1, pp. 78–81, Chicago, Ill, USA, July 2000. View at Publisher · View at Google Scholar
  17. S. J. Roy and P. S. Mainzen Prince, “Protective effects of sinapic acid on cardiac hypertrophy, dyslipidaemia and altered electrocardiogram in isoproterenol-induced myocardial infarcted rats,” European Journal of Pharmacology, vol. 699, no. 1–3, pp. 213–218, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Tiwari, M. Mohan, S. Kasture, A. Maxia, and M. Ballero, “Cardioprotective potential of myricetin in isoproterenol-induced myocardial infarction in wistar rats,” Phytotherapy Research, vol. 23, no. 10, pp. 1361–1366, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Y. Chen, Y.-F. Chen, C.-H. Wu, and H.-Y. Tsai, “What is the effective component in suanzaoren decoction for curing insomnia? Discovery by virtual screening and molecular dynamic simulation,” Journal of Biomolecular Structure and Dynamics, vol. 26, no. 1, pp. 57–64, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. Q.-H. Gao, C.-S. Wu, and M. Wang, “The jujube (Ziziphus Jujuba Mill.) fruit: a review of current knowledge of fruit composition and health benefits,” Journal of Agricultural and Food Chemistry, vol. 61, no. 14, pp. 3351–3363, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. C.-H. Shou, J. Wang, X.-X. Zheng, and D.-W. Guo, “Inhibitory effect of jujuboside A on penicillin sodium induced hyperactivity in rat hippocampal CA1 area in vitro,” Acta Pharmacologica Sinica, vol. 22, no. 11, pp. 986–990, 2001. View at Google Scholar · View at Scopus
  22. W. H. Chappell, L. S. Steelman, J. M. Long et al., “Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health,” Oncotarget, vol. 2, no. 3, pp. 135–164, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. B. Ma, T. Sen, L. Asnaghi et al., “βA3/A1-Crystallin controls anoikis-mediated cell death in astrocytes by modulating PI3K/AKT/mTOR and ERK survival pathways through the PKD/Bit1-signaling axis,” Cell Death and Disease, vol. 2, no. 10, article e217, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Marone, V. Cmiljanovic, B. Giese, and M. P. Wymann, “Targeting phosphoinositide 3-kinase-Moving towards therapy,” Biochimica et Biophysica Acta, vol. 1784, no. 1, pp. 159–185, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. D. C. Fingar and J. Blenis, “Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression,” Oncogene, vol. 23, no. 18, pp. 3151–3171, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. B. Vanhaesebroeck, L. Stephens, and P. Hawkins, “PI3K signalling: the path to discovery and understanding,” Nature Reviews Molecular Cell Biology, vol. 13, no. 3, pp. 195–203, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. Y.-P. Ho, C.-W. Kuo, Y.-T. Hsu et al., “β-Actin is a downstream effector of the PI3K/AKT signaling pathway in myeloma cells,” Molecular and Cellular Biochemistry, vol. 348, no. 1-2, pp. 129–139, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Mazzoletti, F. Bortolin, L. Brunelli et al., “Combination of PI3K/mTOR inhibitors: antitumor activity and molecular correlates,” Cancer Research, vol. 71, no. 13, pp. 4573–4584, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. C. J. Richardson, S. S. Schalm, and J. Blenis, “PI3-kinase and TOR: PIKTORing cell growth,” Seminars in Cell and Developmental Biology, vol. 15, no. 2, pp. 147–159, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. G. H. Wang, F. Wang, W. F. Ding et al., “APRIL induces tumorigenesis and metastasis of colorectal cancer cells via activation of the PI3K/Akt pathway,” PLoS ONE, vol. 8, no. 1, Article ID e55298, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. E. B. Borders, C. Bivona, and P. J. Medina, “Mammalian target of rapamycin: biological function and target for novel anticancer agents,” American Journal of Health-System Pharmacy, vol. 67, no. 24, pp. 2095–2106, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Liegl, S. Koenig, J. Siedlecki, C. Haritoglou, A. Kampik, and M. Kernt, “Temsirolimus inhibits proliferation and migration in retinal pigment epithelial and endothelial cells via mTOR inhibition and decreases VEGF and PDGF expression,” PLoS ONE, vol. 9, no. 2, Article ID e88203, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. P. M. LoRusso, “Mammalian target of rapamycin as a rational therapeutic target for breast cancer treatment,” Oncology, vol. 84, no. 1, pp. 43–56, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Vignot, S. Faivre, D. Aguirre, and E. Raymond, “mTOR-targeted therapy of cancer with rapamycin derivatives,” Annals of Oncology, vol. 16, no. 4, pp. 525–537, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Castedo, K. F. Ferri, and G. Kroemer, “Mammalian target of rapamycin (mTOR): pro- and anti-apoptotic,” Cell Death and Differentiation, vol. 9, no. 2, pp. 99–100, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. H. Takeuchi, Y. Kondo, K. Fujiwara et al., “Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors,” Cancer Research, vol. 65, no. 8, pp. 3336–3346, 2005. View at Google Scholar · View at Scopus
  37. C. C. He and D. J. Klionsky, “Regulation mechanisms and signaling pathways of autophagy,” Annual Review of Genetics, vol. 43, pp. 67–93, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. N. Mizushima, T. Yoshimori, and B. Levine, “Methods in mammalian autophagy research,” Cell, vol. 140, no. 3, pp. 313–326, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. V. Škop, M. Cahová, Z. Papácková et al., “Autophagy-lysosomal pathway is involved in lipid degradation in rat liver,” Physiological Research, vol. 61, no. 3, pp. 287–297, 2012. View at Google Scholar · View at Scopus
  40. D. C. Rubinsztein, A. M. Cuervo, B. Ravikumar et al., “In search of an ‘autophagomometer’,” Autophagy, vol. 5, no. 5, pp. 585–589, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. N. Mizushima, A. Yamamoto, M. Matsui, T. Yoshimori, and Y. Ohsumi, “In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker,” Molecular Biology of the Cell, vol. 15, no. 3, pp. 1101–1111, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. T. Shpilka, H. Weidberg, S. Pietrokovski, and Z. Elazar, “Atg8: an autophagy-related ubiquitin-like protein family,” Genome Biology, vol. 12, no. 7, article 226, 2011. View at Publisher · View at Google Scholar · View at Scopus