Influence of the Melissa officinalis Leaf Extract on Long-Term Memory in Scopolamine Animal Model with Assessment of Mechanism of Action

Table 2

Effect of Melissa officinalis leaf extract (200 mg/kg, p.o.) treatment on sedative activity, motor coordination, and memory in rats.

Group		Locomotor activity; number of impulses/5 min]	Motor coordination, exit time [s]	Short-term memory; OR	Long-term memory, latency [s]
MC + H2O	18	390 ± 24	17 ± 3	0.40 ± 0.06	47 ± 14
MC + SC	18	526 ± 48	32 ± 5	0.32 ± 0.05	12 ± 3
MO + H2O	10	231 ± 48	32 ± 7	0.43 ± 0.07	169 ± 11
MO + SC	9	436 ± 60	43 ± 7	0.09 ± 0.11	23 ± 6
HU + H2O	9	515 ± 32	15 ± 2	0.37 ± 0.09	158 ± 14
HU + SC	8	639 ± 71	56 ± 3	0.22 ± 0.06	49 ± 18
RA + H2O	8	406 ± 59	21 ± 5	0.45 ± 0.05	58 ± 28
RA + SC	8	605 ± 55	28 ± 7	0.45 ± 0.05	20 ± 7

Means ± SEM.
Number of animals.
MC + H₂O: control rats.
SC: scopolamine (0.5 mg/kg b.w., i.p.).
HU: huperzine A (0.5 mg/kg b.w., p.o.).
RA: rosmarinic acid (10 mg/kg b.w., p.o.).
Expressed as ratio ; for details see Section 3.
Versus MC + H₂O, .
Versus MC + SC, .