Sakuranetin Inhibits Inflammatory Enzyme, Cytokine, and Costimulatory Molecule Expression in Macrophages through Modulation of JNK, p38, and STAT1

Figure 4

Sakuranetin decreases the expression of costimulatory molecules. Mouse peritoneal macrophages were stimulated with LPS in the presence of sakuranetin for 24 h. The cells were stained for FITC-conjugated CD40 antibody or PE-conjugated CD86 antibody and analyzed using flow cytometry. (a) Representative histograms are shown. (b) The value of mean fluorescence intensity (MFI) was analyzed and data are expressed as mean ± SD (). and versus controls (cells treated with LPS only).

(a)

(b)