Structural Aspects of Antioxidant and Genotoxic Activities of Two Flavonoids Obtained from Ethanolic Extract of Combretum leprosum
Table 3
Cytotoxicity and antioxidant effect of FCL2 product isolated from C. leprosum ethanolic extract in S. cerevisiae.
Treatment
Yeast strains
WT
sod1Δ
sod2Δ
sod1Δsod2Δ
NC
100.0 ± 0.0
100.0 ± 0.0
100.0 ± 0.0
100.0 ± 0.0
FCL2 10 μg/mL
97.3 ± 1.98
94.05 ± 6.43
98.80 ± 1.56
96.50 ± 0.85
FCL2 50 μg/mL
98.05 ± 2.62
94.65 ± 3.89
95.10 ± 2.26
96.25 ± 1.91
FCL2 100 μg/mL
96.90 ± 4.24
93.60 ± 4.38
96.40 ± 4.95
97.10 ± 1.13
FCL2 500 μg/mL
93.70 ± 1.13
94.80 ± 1.27
96.05 ± 3.75
97.80 ± 2.97
PC: H2O2 5 mM
63.03 ± 4.12
16.27 ± 4.88
19.10 ± 4.03
19.33 ± 2.10
FCL2 10 μg/mL + H2O2
63.15 ± 10.25
31.60 ± 2.40
39.10 ± 1.13
33.20 ± 2.95
FCL2 50 μg/mL + H2O2
68.95 ± 1.06
38.0 ± 2.12
42.80 ± 2.97
66.53 ± 5.75
FCL2 100 μg/mL + H2O2
71.15 ± 1.77
41.60 ± 5.52
44.0 ± 2.55
75.15 ± 2.90
FCL2 500 μg/mL + H2O2
71.10 ± 3.11
35.80 ± 7.50
31.35 ± 2.76
66.05 ± 7.71
NC: negative control (solvent: DMSO). Positive control (H2O2). Data significant in relation to oxidant-treated samples at , , and /one-way ANOVA, Tukey’s multiple comparison test.
