Structural Aspects of Antioxidant and Genotoxic Activities of Two Flavonoids Obtained from Ethanolic Extract of Combretum leprosum
Table 4
Cytotoxicity and antioxidant effect of FCL5 product isolated from C. leprosum ethanolic extract in S. cerevisiae.
Treatment
Yeast strains
WT
sod1Δ
sod2Δ
sod1Δsod2Δ
NC
100.0 ± 0.0
100.0 ± 0.0
100.0 ± 0.0
100.0 ± 0.0
FCL5 10 μg/mL
99.65 ± 3.32
99.35 ± 0.78
98.20 ± 1.98
93.75 ± 5.44
FCL5 50 μg/mL
98.15 ± 2.33
99.40 ± 3.82
94.0 ± 5.37
92.20 ± 4.95
FCL5 100 μg/mL
95.05 ± 0.64
96.80 ± 1.56
93.35 ± 4.88
92.25 ± 0.64
FCL5 500 μg/mL
97.25 ± 3.61
93.65 ± 1.63
87.55 ± 1.20
83.30 ± 3.68
PC: H2O2 5 mM
63.03 ± 4.12
16.27 ± 4.88
19.10 ± 4.03
19.33 ± 2.10
FCL5 10 μg/mL + H2O2
68.05 ± 3.04
29.90 ± 0.28
38.30 ± 9.33
35.20 ± 2.40
FCL5 50 μg/mL + H2O2
70.55 ± 2.48
36.70 ± 4.53
43.80 ± 1.41
45.10 ± 3.96
FCL5 100 μg/mL + H2O2
69.50 ± 5.52
42.35 ± 3.04
42.20 ± 4.38
51.25 ± 6.29
FCL5 500 μg/mL + H2O2
68.15 ± 3.75
29.50 ± 1.70
35.25 ± 5.16
29.85 ± 1.49
NC: negative control (solvent: DMSO). Positive control (H2O2). Data significant in relation to oxidant-treated samples at , , and /one-way ANOVA, Tukey’s multiple comparison test.
