Structural Aspects of Antioxidant and Genotoxic Activities of Two Flavonoids Obtained from Ethanolic Extract of Combretum leprosum

Table 7

Induction of reversion of point mutation for his1-798, ochre allele lys1-1, and frameshift mutation (hom3-10) in S. cerevisiae haploid strain XV185-14c after treatment with FCL5 isolated product from ethanolic extract of C. leprosum.

Agent	Treatment (μg/mL)	Survival (%)	LYS1/10^8 survivors	HIS1/10^7 survivors	HOM3/10^8 survivors
STAT cells treated in PBS
NC	0	100.00	4.00 ± 2.83	10.50 ± 0.71	4.0 ± 1.41
4-NQO	1.0 μg/mL	39.97	20.85 ± 2.48	49.50 ± 9.19	13.50 ± 4.95
FCL5	10 μg/mL	89.60	3.27 ± 2.13	7.49 ± 0.71	4.46 ± 3.17
	50 μg/mL	85.67	6.94 ± 0.55	10.24 ± 2.10	4.78 ± 1.90
	100 μg/mL	92.70	6.20 ± 0.29	7.50 ± 0.87	5.10 ± 0.36
	500 μg/mL	76.57	5.95 ± 0.21	9.52 ± 3.10	7.00 ± 1.27

Locus-specific revertants. Locus nonspecific revertants. Mean and standard deviation per three independent experiments. Negative control (solvent). Positive control. Data significant in relation to negative control group (solvent) at ; /one-way ANOVA, Tukey’s multiple comparison test.